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NCT06167772: SOFA
Leucine-enriched Branched-chain Amino Acid on Muscle Thickness, Interleukin-6, SOFA Score in Critical Illness
NA trial testing BCAA in Critical Illness in 40 participants. Completed in 10 May 2024.
10 May 2024
Quick facts
| Lead sponsor | Indonesia University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | supportive care |
| Enrollment | 40 |
| Start date | 14 December 2023 |
| Primary completion | 10 May 2024 |
| Estimated completion | 10 May 2024 |
| Sites | 2 locations across Indonesia |
Drugs / interventions tested
- BCAA — full drug profile →
- Standard nutrition
- Standard physiotherapy
Conditions studied
- Critical Illness — all drugs for Critical Illness →
- Muscle Wasting — all drugs for Muscle Wasting →
Sponsor
Indonesia University
Who can join
Adults 18 to 65, any sex, with Critical Illness or Muscle Wasting. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this clinical trial study is to test effects of leucine-enriched branched-chain amino acid (BCAA) in critically ill patients. The main questions it aims to answer are: • How are the changes in muscle thickness between groups at baseline and end of study • Is there a decrease in interleukin-6 levels between groups at baseline and end of study • Is there a decrease in sequential organ failure assessment score between groups at baseline and end of study. Participants will be given leucine-enriched branched-chain amino acid 40 g/day enterally or parenterally for 10 days. Researchers will compare with control groups to see if there is any changes between groups at baseline and end of study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
High leucine branched-chain amino acids supplementation ameliorates quadriceps femoris muscle thickness reduction and attenuates interleukin-6 in critically ill patients: A randomised controlled trial.
Wulandari Y, Aditianingsih D, Sunardi D, Prasetyo M, et al · · 2026 · PMID 41325937 · DOI 10.1016/j.clnesp.2025.11.153
Verify or expand the search:
- PubMed search for NCT06167772
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06167772 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indonesia University
- Last refreshed: 23 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06167772.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing