Maintaining Immune and Mitochondrial Functions in Old Adults With SAfe Nutrition. (MIMOSA)

NCT05324475 NA RECRUITING

Aging is associated with an increased inflammation named "inflammageing" and with an altered immune response. Different mechanisms have been proposed to explain the phenomenon of inflammageing and increased oxidative stress: deficiencies in essential amino acids, and some micronutrients have an important impact and may induce immune cell dysregulation. Mitochondrial dysfunction may explain the complex relationship between malnutrition sarcopenia, immune dysfunction and aging. Therefore, a personalized nutritional strategy aiming to improve mitochondrial function, decrease oxidative stress, down-regulate inflammation and restore immunity appears to be a logical approach in order to treat malnutrition and its biological and clinical consequences. MIMOSA will investigate the role of nutritional supplements in rescuing altered mitochondrial function and redox state imbalance.

Details

Lead sponsor	Patrizia D'Amelio
Phase	NA
Status	RECRUITING
Enrolment	240
Start date	Tue Apr 01 2025 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu Mar 30 2028 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Malnutrition
• Sarcopenia

Interventions

• BCAA
• Micronutriments
• standard treatment + placebo

Countries

Switzerland