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NCT07177183: SECRET-VENT
Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure
NA trial testing Dietary supplement creatine in Prolonged Mechanical Ventilation in 492 participants. Currently enrolling.
31 December 2027
Quick facts
| Lead sponsor | University Hospital Ostrava |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 492 |
| Start date | 2 February 2026 |
| Primary completion | 31 December 2027 |
| Estimated completion | 2 February 2028 |
| Sites | 2 locations across Czechia |
Drugs / interventions tested
- Dietary supplement creatine
- Dietary supplement - placebo
- No intervention
Conditions studied
- Prolonged Mechanical Ventilation — all drugs for Prolonged Mechanical Ventilation →
- Critical Illness — all drugs for Critical Illness →
Sponsor
University Hospital Ostrava
Who can join
18 and older, any sex, with Prolonged Mechanical Ventilation or Critical Illness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07177183
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Prolonged Mechanical Ventilation
Currently open trials in the same condition.
- NCT06125210 — Application of Early Bundle Management of Mechanical Ventilation to Prevent Ventilator Dependence in Children · NA · recruiting
- NCT05634135 — Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation · recruiting
Other University Hospital Ostrava trials
Trials by the same sponsor.
- NCT07374289 — On Scene ECPR in Ostrava · NA · recruiting
- NCT07041086 — Prehospital ECPR in Moravia Silesia Region · recruiting
- NCT06921746 — Changes in the Urinary Microbiome and Metabolome During Treatment of the Overactive Bladder in Female Patients · recruiting
- NCT07009652 — Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian · recruiting
- NCT06933199 — Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07177183 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital Ostrava
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07177183.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing