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NCT05712798
Physiological Responses to Exercise Tests in Primary Ciliary Dyskinesia Compared With Healthy Individuals
trial testing No intervention in Primary Ciliary Dyskinesia in 46 participants. Completed in 7 October 2023.
7 October 2023
Quick facts
| Lead sponsor | Hacettepe University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 46 |
| Start date | 7 October 2020 |
| Primary completion | 7 October 2023 |
| Estimated completion | 7 October 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- No intervention
Conditions studied
- Primary Ciliary Dyskinesia — all drugs for Primary Ciliary Dyskinesia →
Sponsor
Hacettepe University
Who can join
Adults 8 to 18, any sex, with Primary Ciliary Dyskinesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The individuals with primary ciliary dyskinesia (PCD) have lower aerobic fitness and anaerobic performance than healthy individuals. Cardiopulmonary exercise test (CPET) provides an integrated assessment of integrative exercise responses involving the pulmonary, cardiovascular, hematopoietic, neuropsychological, and skeletal muscle systems that are not adequately reflected by measurement of the function of organ systems. Maximum oxygen consumption is measured by performing gas exchange analysis with CPET, offering an objective measure of cardiorespiratory fitness. The six-minute walk test (6MWT) and the shuttle walk test (SWT) are field tests that produce oxygen consumption results similar to those during CPET. There is a need to determine the physiological responses to CPET, SWT and 6MWT in individuals with PCD. Additionally, the physiological responses of individuals with PCD to different exercise tests will be compared with the responses of healthy individuals. Low aerobic capacity in individuals with PCD may affect the physical, emotional, and social lives of individuals. This influence may cause a decrease in the quality of life of individuals with PCD. The relationship between exercise capacity and quality of life in individuals with PSD will be investigated with this study.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Physiological responses to cardiopulmonary and field exercise tests in primary ciliary dyskinesia compared with healthy peers.
Cakmak-Onal A, Kocaaga E, Sonbahar-Ulu H, Calik E, et al · · 2026 · PMID 41186743 · DOI 10.1007/s00421-025-06019-2
Verify or expand the search:
- PubMed search for NCT05712798
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05712798 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Hacettepe University
- Last refreshed: 1 July 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05712798.
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