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NCT05685186
A Longitudinal, Observational Study of Primary Ciliary Dyskinesia in Adults
trial testing Spirometry in Primary Ciliary Dyskinesia in 50 participants. Participants enrolled and being followed up; not accepting new ones.
28 April 2025
Quick facts
| Lead sponsor | ReCode Therapeutics |
|---|---|
| Status | Active, enrolled |
| Study type | OBSERVATIONAL |
| Enrollment | 50 |
| Start date | 8 March 2023 |
| Primary completion | 28 April 2025 |
| Estimated completion | 30 June 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Spirometry
- Multiple Breath Washout (MBW)
- Mucociliary Clearance (MCC)
- CT of the chest
- MRI of the chest
Conditions studied
- Primary Ciliary Dyskinesia — all drugs for Primary Ciliary Dyskinesia →
Sponsor
ReCode Therapeutics — full company profile →
Who can join
Adults 18 to 60, any sex, with Primary Ciliary Dyskinesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The goal of this observational study is to characterize clinical measures and biomarkers of airway disease in adults with primary ciliary dyskinesia (PCD) and in a group of healthy volunteers (HV) to establish normative values. Lung function, mucociliary clearance, radiological findings, and clinical findings will be assessed. Furthermore, quality of life will be assessed using QOL-PCD, a disease specific questionnaire.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Optimized lipid nanoparticles (LNPs) for organ-selective nucleic acids delivery <i>in vivo</i>.
Zhang T, Yin H, Li Y, Yang H, et al · · 2024 · cited 42× · PMID 38770138 · DOI 10.1016/j.isci.2024.109804
Verify or expand the search:
- PubMed search for NCT05685186
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Primary Ciliary Dyskinesia
Currently open trials in the same condition.
- NCT07274631 — A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine · recruiting
- NCT07029594 — Thermal Spa Treatment and Improvement of Primary Ciliary Dyskinesia · NA · recruiting
- NCT07288827 — Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia · NA · recruiting
- NCT04602481 — Living With Primary Ciliary Dyskinesia (Living With PCD) · recruiting
- NCT03704207 — Utility of PCD Diagnostics to Improve Clinical Care · NA · recruiting
Other ReCode Therapeutics trials
Trials by the same sponsor.
- NCT06633757 — Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clea · Phase 1 · active not recruiting
- NCT06600425 — A Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults With PCD · Phase 1 · completed
- NCT06237335 — A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants Wi · Phase 2 · recruiting
- NCT05737485 — Study Evaluating the Safety and Tolerability of RCT1100 in Healthy and PCD Subjects · Phase 1 · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05685186 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by ReCode Therapeutics
- Last refreshed: 29 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05685186.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing