NCT05569590

Efficacy of Desensitizing Agent,Propolis After an In-office Vital Tooth Bleaching.

Completed NA Last updated 6 October 2022

What this trial tests

NA trial testing Propolis in Post Operative Pain in 90 participants. Completed in 22 June 2022.

Timeline

14 May 2021

Primary endpoint
25 December 2021

22 June 2022

Quick facts

Lead sponsor	Dow University of Health Sciences
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	prevention
Enrollment	90
Start date	14 May 2021
Primary completion	25 December 2021
Estimated completion	22 June 2022
Sites	1 location across Pakistan

Drugs / interventions tested

• Propolis — full drug profile →
• hydrogen peroxide 35% — full drug profile →
• fluoride varnish

Conditions studied

• Post Operative Pain — all drugs for Post Operative Pain →

Sponsor

Dow University of Health Sciences

Who can join

Adults 18 to 30, any sex, with Post Operative Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study was conducted to evaluate the efficacy of desensitizing agent Propolis, after an in -office vital tooth bleaching and to compare its desensitizing effect to traditionally used desensitizing agent fluoride varnish.

Methods: Considering the inclusion and exclusion criteria 90 patients will be selected at the OPD of Dow University of Health Sciences Ojha campus with mild to moderate discoloration and randomly divided in to three groups group A control group (fluoride varnish) group B Propolis and group C Propolis mixed with bleaching agent. After performing the bleaching procedure respective desensitizing agent was applied to each group for 10 minutes. Visual analogue scale and Schiff's scale were used to assess the sensitivity after completion of treatment. Subjective non stimulated assessment of sensitivity was done by using the visual analogue scale from day 1 till day 7 on given Performa and Objective stimulated assessment of sensitivity was done at the dental office on day 1 right after the procedure and at day 7 on follow-up after one week.

Kruskal-Wallis test was applied to check median pain score and sensitivity difference between and among the groups. Mann-Whitney U test was applied to check further pairwise comparison between the groups.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Propolis and Their Active Constituents for Chronic Diseases.
   Chavda VP, Chaudhari AZ, Teli D, Balar P, et al · · 2023 · cited 18× · PMID 36830794 · DOI 10.3390/biomedicines11020259