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NCT07227064
Methadone in THA for Post-op Pain and Opioid Reduction
Phase 3 trial testing Methadone in Post Operative Pain in 162 participants. Currently enrolling.
31 December 2026
Quick facts
| Lead sponsor | Medical University of South Carolina |
|---|---|
| Phase | Phase 3 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 162 |
| Start date | 12 January 2026 |
| Primary completion | 31 December 2026 |
| Estimated completion | 31 January 2027 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Methadone (METHADONE) — full drug profile →
Conditions studied
- Post Operative Pain — all drugs for Post Operative Pain →
- Total Hip Arthroplasty — all drugs for Total Hip Arthroplasty →
Sponsor
Medical University of South Carolina
Who can join
Adults 18 to 75, any sex, with Post Operative Pain or Total Hip Arthroplasty. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This randomized, double-blind controlled trial investigates whether intraoperative intravenous methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total hip arthroplasty under spinal anesthesia with mepivacaine. The primary outcome is patient-reported pain on a visual analog scale (VAS) 30-60 minutes after arrival in the post-anesthesia care unit (PACU). Secondary outcomes include opioid use, pain scores over time, incidence of nausea/vomiting, and quality of recovery. A total of 162 subjects will be enrolled at MUSC surgical sites.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07227064
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Methadone
Trials testing the same drug.
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- NCT06810336 — Pain Control and Quality of Recovery After Intravenous Methadone Versus Intravenous Remifentanil in Craniotomy Surgery · EARLY_PHASE1 · not yet recruiting
- NCT06576830 — Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia · Phase 4 · recruiting
- NCT06525740 — Methadone Versus Intrathecal Hydromorphone for Postoperative Pain Relief in Gynecologic Cancer Undergoing Surgery · Phase 4 · recruiting
Other recruiting trials for Post Operative Pain
Currently open trials in the same condition.
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- NCT07226076 — Methadone in TKA for Post-op Pain and Opioid Reduction · Phase 3 · recruiting
- NCT07349810 — Post Operative Infusion Pump Pain Study · Phase 4 · recruiting
- NCT07210164 — Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study · NA · recruiting
Other Medical University of South Carolina trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07227064 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Medical University of South Carolina
- Last refreshed: 5 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07227064.
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