Last reviewed · How we verify
NCT05393661: FIRST-IN
Focused Intensive Repeated Stepping During Inpatient Rehabilitation Poststroke - A Quality Improvement Project
trial testing inpatient physical therapy poststroke in Stroke, Acute in 2,000 participants. Currently enrolling.
31 December 2030
Quick facts
| Lead sponsor | Indiana University |
|---|---|
| Status | Recruiting now |
| Study type | OBSERVATIONAL |
| Enrollment | 2,000 |
| Start date | 1 January 2017 |
| Primary completion | 31 December 2030 |
| Estimated completion | 31 December 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- inpatient physical therapy poststroke
Conditions studied
- Stroke, Acute — all drugs for Stroke, Acute →
- Gait, Hemiplegic — all drugs for Gait, Hemiplegic →
Sponsor
Indiana University
Who can join
Adults 18 to 89, any sex, with Stroke, Acute or Gait, Hemiplegic. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this quality improvement project was first to monitor usual physical therapy care (types \& cardiovascular intensity of interventions and amount of stepping practice provided) and outcomes. Following which educational training and support was provided to treating physical therapists to encourage implementation of evidence-based practices. Specifically, therapists were encouraged to prioritize the practice of walking, particularly at higher cardiovascular intensities during scheduled therapy sessions. Fidelity metrics in the form of chart audits and pedometer-based step counts were utilized to determine compliance with the evidence-based intervention and ultimately investigated for potential effects on patient outcome measures.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Increasing the Amount and Intensity of Stepping Training During Inpatient Stroke Rehabilitation Improves Locomotor and Non-Locomotor Outcomes.
Henderson CE, Plawecki A, Lucas E, Lotter JK, et al · · 2022 · cited 20× · PMID 36004813 · DOI 10.1177/15459683221119759
Verify or expand the search:
- PubMed search for NCT05393661
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05393661 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Indiana University
- Last refreshed: 15 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05393661.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing