Last reviewed · How we verify
NCT06825897: DIRECT
Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiography SuiTe
NA trial testing Conventional Triage for Mechanical Thrombectomy in Stroke, Acute in 2,039 participants. Currently enrolling.
30 April 2028
Quick facts
| Lead sponsor | Santiago Ortega Gutierrez |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 2,039 |
| Start date | 27 January 2026 |
| Primary completion | 30 April 2028 |
| Estimated completion | 30 April 2028 |
| Sites | 6 locations across United States |
Drugs / interventions tested
- Conventional Triage for Mechanical Thrombectomy
- Direct Transfer to Angiography Suite (DTAS
Conditions studied
- Stroke, Acute — all drugs for Stroke, Acute →
Sponsor
Santiago Ortega Gutierrez
Who can join
18 and older, any sex, with Stroke, Acute. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to compare two strategies for treating adults with suspected large vessel occlusion stroke within 7 hours of symptom onset. Researchers will evaluate whether direct transfer to the neurointerventional angiography suite improves recovery and reduces disability compared to the conventional approach of first being evaluated in the emergency department. The study will also assess safety and other health outcomes to guide care for stroke patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Neurointerventional Advances in 2025.
Mehta A, Sheth SA, Jadhav AP. · · 2026 · PMID 42088336 · DOI 10.1161/svin.125.002280
Verify or expand the search:
- PubMed search for NCT06825897
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Stroke, Acute
Currently open trials in the same condition.
- NCT06658197 — Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke · Phase 3 · recruiting
- NCT07253870 — Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients · NA · recruiting
- NCT06941753 — Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge · NA · recruiting
- NCT06123650 — Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia. · NA · recruiting
- NCT06710028 — Trustworthy Artificial Intelligence for Improvement of Stroke Outcomes · recruiting
Other Santiago Ortega Gutierrez trials
Trials by the same sponsor.
- NCT07001852 — EnDOvascular Therapy for Late WiNdow IschEmic Stroke Patients Selected bY AutoMatic Plain ComputErized Tomography · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06825897 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Santiago Ortega Gutierrez
- Last refreshed: 13 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06825897.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing