NCT07470099

The Role of Breathing Perception in Respiratory Control

Not yet recruiting NA Last updated 13 March 2026

What this trial tests

NA trial testing Ambient Noise in Work of Breathing in 15 participants. Not yet recruiting.

Timeline

1 June 2027

Primary endpoint
1 June 2027

30 September 2028

Quick facts

Lead sponsor	Indiana University
Phase	NA
Status	Not yet recruiting
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	15
Start date	1 June 2027
Primary completion	1 June 2027
Estimated completion	30 September 2028
Sites	1 location across United States

Drugs / interventions tested

• Ambient Noise
• Increased Auditory Feedback
• Noise Distraction

Conditions studied

• Work of Breathing — all drugs for Work of Breathing →

Sponsor

Indiana University

Who can join

Adults 18 to 40, any sex, with Work of Breathing. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Warfighters are frequently exposed to environments and life-support systems that increase breathing resistance and the work of breathing (WOB), such as aircraft on-board oxygen generation systems and underwater breathing apparatuses. Elevated WOB then increases the perception of breathing difficulty (dyspnea) and has been associated with impaired cognitive performance, including slower reaction time and reduced accuracy during attention-demanding tasks. These effects are particularly concerning in operational settings that require rapid decision-making and precise motor responses.

Despite growing recognition of this issue, critical gaps remain regarding strategies to mitigate the perceptual and cognitive consequences of elevated inspiratory resistance, especially under realistic operational stressors. The objective of this experiment is to determine whether modifying the sensory perception of breathing alters breathing perception and cognitive performance during inspiratory resistance. Auditory feedback of ventilation will be manipulated (normal, reduced, or amplified) to assess whether altering breathing-related sensory input affects breathing perception and cognitive performance without changing mechanical load.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.