Last reviewed · How we verify
NCT05221905
Effects of Inorganic Nitrate and Intensity of Exercise on Cardiovascular Health in Post-Menopausal Females
Phase 1 trial testing BEET IT - Concentrate Beet root juice in Vascular Dilation in 24 participants. Completed in 1 April 2023.
1 April 2023
Quick facts
| Lead sponsor | University of Virginia |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 24 |
| Start date | 1 November 2021 |
| Primary completion | 1 April 2023 |
| Estimated completion | 1 April 2023 |
| Sites | 1 location across United States |
Drugs / interventions tested
- BEET IT - Concentrate Beet root juice — full drug profile →
- BEET IT - Concentrate Beet root juice (nitrate depleted) — full drug profile →
Conditions studied
- Vascular Dilation — all drugs for Vascular Dilation →
- Arterial Stiffness — all drugs for Arterial Stiffness →
Sponsor
University of Virginia
Who can join
Adults 45 to 75, female only, with Vascular Dilation or Arterial Stiffness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Post-menopausal females experience elevated cardiovascular disease risk (CVD), compared to premenopausal females and age-matched males. Current exercise guidelines appear inadequate to ameliorate this increased risk and higher intensity exercise may be necessary. Oral inorganic nitrate supplementation enhances both exercise performance and CVD risk profile in several clinical conditions. However, the effects of this intervention in post-menopausal females is unexplored.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The acute effects of exercise intensity and inorganic nitrate supplementation on vascular health in females after menopause.
Hogwood AC, Ortiz de Zevallos J, Weeldreyer N, Clark JR, et al · · 2023 · cited 6× · PMID 37795531 · DOI 10.1152/japplphysiol.00559.2023
Verify or expand the search:
- PubMed search for NCT05221905
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Vascular Dilation
Currently open trials in the same condition.
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Other University of Virginia trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05221905 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Virginia
- Last refreshed: 30 November 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05221905.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing