Last reviewed · How we verify
NCT05545865
Chardonnay Marc and Vascular Response
NA trial testing Low Flavanol Cocoa Powder in Cardiovascular Diseases in 5 participants. Currently enrolling.
24 August 2026
Quick facts
| Lead sponsor | University of California, Davis |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | other |
| Enrollment | 5 |
| Start date | 1 September 2022 |
| Primary completion | 24 August 2026 |
| Estimated completion | 24 August 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Low Flavanol Cocoa Powder
- High Flavanol Cocoa Powder
- Vine to Bar Chocolate - 2 servings
- Vine to Bar Chocolate - 1 serving
- Vine to Bar Chocolate covered almonds
Conditions studied
- Cardiovascular Diseases — all drugs for Cardiovascular Diseases →
- Vascular Dilation — all drugs for Vascular Dilation →
- Oxidative Stress — all drugs for Oxidative Stress →
Sponsor
University of California, Davis
Who can join
Adults 30 to 50, male only, with Cardiovascular Diseases or Vascular Dilation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT05545865
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05545865 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of California, Davis
- Last refreshed: 18 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05545865.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing