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NCT07298941: REST
Resilience Enhancement Following Sleep Treatment
Phase 2 trial testing Cognitive-behavioral therapy for insomnia (CBTi) in Chronic Low Back Pain (CLBP) in 300 participants. Currently enrolling.
30 October 2029
Quick facts
| Lead sponsor | University of Virginia |
|---|---|
| Phase | Phase 2 |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 16 December 2025 |
| Primary completion | 30 October 2029 |
| Estimated completion | 30 April 2030 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Cognitive-behavioral therapy for insomnia (CBTi)
- CBTi + Savoring Meditation
- CBTi + Pain Education
Conditions studied
- Chronic Low Back Pain (CLBP) — all drugs for Chronic Low Back Pain (CLBP) →
- Insomnia — all drugs for Insomnia →
Sponsor
University of Virginia
Who can join
18 and older, any sex, with Chronic Low Back Pain (CLBP) or Insomnia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary objective of this study is to evaluate the efficacy of an adaptive intervention targeting both insomnia and positive affect in improving pain outcomes for adults with chronic low back pain (cLBP) and comorbid insomnia. Specifically, the study tests whether augmenting a cognitive behavioral therapy for insomnia (CBTi) program with a meditation intervention (Savoring Meditation) or a Pain Education intervention will result in greater reductions in pain intensity. Secondary objectives include evaluating improvements in insomnia severity, positive and negative affect, and overall quality of life.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07298941
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Chronic Low Back Pain (CLBP)
Currently open trials in the same condition.
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- NCT07161661 — Chronic Low Back Pain and Osteopathic Manipulation Treatment · NA · recruiting
- NCT07215104 — A Prospective Evaluation of Spinal Cord Induced Muscle Stimulation (MuscleSCS) for the Treatment of Chronic Low Back Pai · NA · recruiting
- NCT07163117 — Lumber Stabilization Exercise Versus Back Endurance Exercise Among Female University Students · NA · recruiting
- NCT07141069 — Art Therapy for Adults With Chronic Low Back Pain · NA · recruiting
Other University of Virginia trials
Trials by the same sponsor.
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- NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
- NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting
- NCT07010146 — Role of Estrogen on Skeletal Outcomes in FHA · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07298941 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Virginia
- Last refreshed: 23 December 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07298941.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing