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NCT05880355
Multimodality Cardiovascular Imaging for the Translation of Therapies for Vascular Activation After MI
EARLY_PHASE1 trial testing Dapansutrile in Myocardial Infarction in 60 participants. Not yet recruiting.
31 December 2028
Quick facts
| Lead sponsor | University of Virginia |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 April 2026 |
| Primary completion | 31 December 2028 |
| Estimated completion | 30 January 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Dapansutrile — full drug profile →
- Placebo
Conditions studied
- Myocardial Infarction — all drugs for Myocardial Infarction →
Sponsor
University of Virginia
Who can join
Adults 25 to 99, any sex, with Myocardial Infarction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Subjects with urgently reperfused type I myocardial infarction (MI) will be recruited and randomized to receive either placebo or the oral inflammasome (NLRP3) inhibitor dapansutrile. The primarily outcome measure will be carotid plaque volume change over 6 months; secondary outcome measures will be plaque inflammatory activity and coronary microvascular function.
Publications & conference data
5 peer-reviewed publications reference this trial (live from Europe PMC):
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders.
Ramachandran R, Manan A, Kim J, Choi S. · · 2024 · cited 67× · PMID 38945951 · DOI 10.1038/s12276-024-01261-8 -
Inflammasomes in neurodegenerative diseases.
Wang Q, Yang S, Zhang X, Zhang S, et al · · 2024 · cited 13× · PMID 39710713 · DOI 10.1186/s40035-024-00459-0 -
Aldosterone: From Essential Tubular Regulator to Pathological Driver-Physiology, Disease, and Therapeutic Advances.
Strizzi CT, D'Ambrosio V, Grandaliano G, Pesce F. · · 2025 · cited 2× · PMID 41009398 · DOI 10.3390/ijms26188829 -
Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: From action mechanism to therapeutic target in clinical trials.
Zhang CY, Liu S, Sui YX, Yang M. · · 2025 · cited 1× · PMID 39958558 · DOI 10.4251/wjgo.v17.i2.100094 -
The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities.
Zou C, Jiang S, Li H, Zhao K, et al · · 2026 · PMID 41799937 · DOI 10.1002/mco2.70660
Verify or expand the search:
- PubMed search for NCT05880355
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Dapansutrile
Trials testing the same drug.
- NCT06047262 — Dapansutrile in Diabetes and Diabetes-Related Complications - Dapan-Dia · Phase 2 · recruiting
- NCT05658575 — Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare · Phase 2, PHASE3 · recruiting
- NCT04971499 — A Study of Dapansutrile Plus Pembrolizumab in Patients With PD-1 Refractory Advanced Melanoma · Phase 1, PHASE2 · active not recruiting
Other recruiting trials for Myocardial Infarction
Currently open trials in the same condition.
- NCT07257198 — Aspirin-free Strategy With Ticagrelor in Patients With a Myocardial Infarction Treated Medically Alone · Phase 3 · recruiting
- NCT07402642 — Effect of Early Educational Intervention on Cardiovascular Risk Factors After Acute Coronary Syndrome · NA · recruiting
- NCT07301034 — A Research Study to Look at the Effect of Ziltivekimab on Plaque in the Blood Vessels of the Heart, Compared to Placebo, · Phase 3 · recruiting
- NCT07142265 — Evaluation of 1-Year Clinical Outcomes With Early Inclisiran Initiation in Post-MI Patients · recruiting
- NCT07138911 — Effect of Home-based Exercise Plan Mediated by Use of Digital Health App on Kinesiophobia and Functional Capacity · NA · recruiting
Other University of Virginia trials
Trials by the same sponsor.
- NCT07405645 — Stereotactic MRI-guided Focused Ultrasound Mesencephalotomy · NA · recruiting
- NCT07146685 — Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study · Phase 4 · not yet recruiting
- NCT07298941 — Resilience Enhancement Following Sleep Treatment · Phase 2 · recruiting
- NCT07036315 — Meaning in Music-Based Pain Modulation · NA · recruiting
- NCT07010146 — Role of Estrogen on Skeletal Outcomes in FHA · Phase 2 · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05880355 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Virginia
- Last refreshed: 4 June 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05880355.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing