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NCT05016414: STOP-VIIP
Countermeasures for Visual Impairment in Astronauts
NA trial testing Lower body negative pressure in Space Flight Associated Neuro-ocular Syndrome in 10 participants. Completed in 1 March 2020.
1 March 2020
Quick facts
| Lead sponsor | University of Texas Southwestern Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 10 |
| Start date | 1 March 2019 |
| Primary completion | 1 March 2020 |
| Estimated completion | 1 March 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Lower body negative pressure
Conditions studied
- Space Flight Associated Neuro-ocular Syndrome — all drugs for Space Flight Associated Neuro-ocular Syndrome →
Sponsor
University of Texas Southwestern Medical Center
Who can join
Adults 18 to 55, any sex, with Space Flight Associated Neuro-ocular Syndrome. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study is being done to prevent changes in the vision of astronauts during prolonged residence on the International Space Station or a mission to Mars. This project will provide data about the efficacy of lower body negative pressure to mimic daily upright posture by intermittently lowering central venous pressure while in simulated microgravity (3 days of bed rest). The investigators expect that 3 days of bed rest will increase choroid thickness, and choroid area. The investigators hypothesize that nightly LBNP (-20mmHg) will prevent these changes.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effect of Nightly Lower Body Negative Pressure on Choroid Engorgement in a Model of Spaceflight-Associated Neuro-ocular Syndrome: A Randomized Crossover Trial.
Hearon CM, Dias KA, Babu G, Marshall JET, et al · · 2022 · cited 17× · PMID 34882176 · DOI 10.1001/jamaophthalmol.2021.5200 -
Assessment of venous pressure by compression sonography of the internal jugular vein during 3 days of bed rest.
Hearon CM, Peters K, Dias KA, Macnamara JP, et al · · 2023 · cited 4× · PMID 37824038 · DOI 10.1113/ep091372
Verify or expand the search:
- PubMed search for NCT05016414
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other University of Texas Southwestern Medical Center trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05016414 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Texas Southwestern Medical Center
- Last refreshed: 8 September 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05016414.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing