NCT03582501 (LBNP) is a NA clinical trial of Lower body negative pressure in Hypotension and Shock, sponsored by Mayo Clinic.

Who is sponsoring NCT03582501?

NCT03582501 is sponsored by Mayo Clinic.

What drugs are being tested in NCT03582501?

Interventions in NCT03582501: Lower body negative pressure.

What condition does NCT03582501 study?

NCT03582501 studies Hypotension and Shock.

Is NCT03582501 still recruiting?

NCT03582501 is currently completed. Last updated 12 June 2019.

Last reviewed 2019-06-12 · How we verify

NCT03582501: LBNP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Measurement of Hemodynamic Responses to Lower Body Negative Pressure

Completed NA Last updated 12 June 2019

What this trial tests

NA trial testing Lower body negative pressure in Hypotension and Shock in 24 participants. Completed in 23 May 2019.

Timeline

8 January 2019

Primary endpoint
23 May 2019

23 May 2019

Quick facts

Lead sponsor	Mayo Clinic
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	24
Start date	8 January 2019
Primary completion	23 May 2019
Estimated completion	23 May 2019
Sites	3 locations across United States

Drugs / interventions tested

Lower body negative pressure

Conditions studied

Hypotension and Shock — all drugs for Hypotension and Shock →

Sponsor

Mayo Clinic

Who can join

Adults 18 to 55, any sex, with Hypotension and Shock. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will be collecting data on participants undergoing lower body negative pressure (LBNP) to simulate progressive blood loss. The goal of the study is to collect data to allow for development of an algorithm with machine learning to predict blood pressure responses to hypovolemia by analyzing the arterial waveforms collected during LBNP.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Evidence-based Clinical Decision Support Systems for the prediction and detection of three disease states in critical care: A systematic literature review.
Medic G, Kosaner Kließ M, Atallah L, Weichert J, et al · · 2019 · cited 20× · PMID 31824670 · DOI 10.12688/f1000research.20498.2

Verify or expand the search:

Other trials of Lower body negative pressure

Trials testing the same drug.

NCT07139756 — Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension · not yet recruiting
NCT05705115 — Acetated Ringer´s Solution in Experimental Hypovolemia · Phase 4 · unknown
NCT05016414 — Countermeasures for Visual Impairment in Astronauts · NA · completed

Other recruiting trials for Hypotension and Shock

Currently open trials in the same condition.

NCT07322133 — Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) · Phase 4 · recruiting
NCT07022847 — Pleth Variability Index for Predicting Low Blood Pressure During Maintenance Hemodialysis · recruiting
NCT05931601 — Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · recruiting
NCT04760977 — Prehospital Management of Hypotensive Trauma in HEMS · recruiting

Other Mayo Clinic trials

Trials by the same sponsor.

NCT07126548 — A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men · NA · not yet recruiting
NCT07221656 — Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration · not yet recruiting
NCT06891001 — The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, · NA · not yet recruiting
NCT07169799 — Impact of Cryotherapy Spray (Tru-Freeze) for the Eradication of Gastric Antral Vascular Ectasia (ICE-GAVE) · NA · recruiting
NCT07086183 — Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03582501 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mayo Clinic
Last refreshed: 12 June 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03582501.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing