NCT04810923 is a NA clinical trial of i-PRF in Osteoarthritis, sponsored by Ege University.

Who is sponsoring NCT04810923?

NCT04810923 is sponsored by Ege University.

What drugs are being tested in NCT04810923?

Interventions in NCT04810923: i-PRF, Arthrocentesis.

What condition does NCT04810923 study?

NCT04810923 studies Osteoarthritis.

Is NCT04810923 still recruiting?

NCT04810923 is currently completed. Last updated 23 March 2021.

Last reviewed 2021-03-23 · How we verify

NCT04810923

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Application of Injectable Platelet-Rich Fibrin for the Treatment of Temporomandibular Joint Osteoarthritis

Completed NA Last updated 23 March 2021

What this trial tests

NA trial testing i-PRF in Osteoarthritis in 36 participants. Completed in 2 December 2019.

Timeline

2 April 2019

Primary endpoint
2 December 2019

2 December 2019

Quick facts

Lead sponsor	Ege University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	36
Start date	2 April 2019
Primary completion	2 December 2019
Estimated completion	2 December 2019
Sites	1 location across Turkey (Türkiye)

Drugs / interventions tested

i-PRF
Arthrocentesis

Conditions studied

Osteoarthritis — all drugs for Osteoarthritis →

Sponsor

Ege University

Who can join

Adults 18 to 65, any sex, with Osteoarthritis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The authors designed a randomized, controlled, double-blind clinical trial after the ethical approval by the University Ethics Committee. The patients with temporomandibular joint osteoarthritis (TMJ-OA) randomly assigned one of the two treatment groups: intra-articular injection of injectable platelet-rich fibrin (i-PRF) after arthrocentesis procedure as i-PRF group and arthrocentesis procedure alone as control group. The primary outcome variable was pain levels at preoperatively, and postoperatively at 1st, 2nd, 3rd, 6th and 12th month. The secondary outcome variables included maximum mouth opening (MMO), lateral and protrusive movements.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Evolution and mechanistic insights of platelet-derived products in temporomandibular joint regeneration.
Lin C, Jin Y, Li D, Yang Q, et al · · 2026 · PMID 41646866 · DOI 10.3389/fcell.2026.1776592

Verify or expand the search:

Other trials of i-PRF

Trials testing the same drug.

NCT06886438 — Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial · NA · completed
NCT06073535 — The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction · NA · unknown
NCT05916742 — Biofunctionalization of a Volume-stable Collagen Matrix (VCMX) for the Treatment of Single Gingival Recession · NA · unknown
NCT05283668 — Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation · Phase 4 · completed
NCT05640206 — Effect of Injectable Platelet-rich Fibrin on Disc Displacement Without Reduction · NA · completed

Other recruiting trials for Osteoarthritis

Currently open trials in the same condition.

NCT07404891 — Clinical Trial on the Efficacy and Safety of ALT001 in Osteoarthritis · NA · recruiting
NCT07118501 — A Prospective, Post-Market, Clinical Follow-up Study of the Incompass™ Total Ankle System · recruiting
NCT06631638 — EMPHASYS Cup Positioning in THA With Non-Invasive Navigation (Velys Hip Navigation (VHN)) · NA · recruiting
NCT07198750 — "Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis" · NA · recruiting
NCT07006714 — Preoperative Correction of Vitamin D Deficiency in Total Joint Arthroplasty (TJA) · Phase 4 · active not recruiting

Other Ege University trials

Trials by the same sponsor.

NCT07468227 — Effect of Helfer Skin Tap and Vibration on Pain and Fear in Children During Intramuscular Injection · NA · not yet recruiting
NCT07473050 — Virtual Reality-Based 'Health at My Feet' Program for Individuals With Type 2 Diabetes · NA · not yet recruiting
NCT06955338 — Music and VR Effects on Pain, Anxiety, and Fear During Oral Mucositis Care in Leukaemic Children · NA · not yet recruiting
NCT07344532 — Effect of Preoperative Abdominal Effleurage on Postoperative Constipation · NA · not yet recruiting
NCT07417748 — Kinesthetic Exercises on Adults · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04810923 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ege University
Last refreshed: 23 March 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04810923.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing