NCT05283668 is a Phase 4 clinical trial of i-PRF in Gingival Pigmentation, sponsored by Ain Shams University.

Who is sponsoring NCT05283668?

NCT05283668 is sponsored by Ain Shams University.

What drugs are being tested in NCT05283668?

Interventions in NCT05283668: i-PRF, Diode Laser.

What condition does NCT05283668 study?

NCT05283668 studies Gingival Pigmentation.

Is NCT05283668 still recruiting?

NCT05283668 is currently completed. Last updated 17 March 2022.

Last reviewed 2022-03-17 · How we verify

NCT05283668

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation

Completed Phase 4 Last updated 17 March 2022

What this trial tests

Phase 4 trial testing i-PRF in Gingival Pigmentation in 8 participants. Completed in 30 January 2022.

Timeline

20 February 2020

Primary endpoint
20 January 2022

30 January 2022

Quick facts

Lead sponsor	Ain Shams University
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	8
Start date	20 February 2020
Primary completion	20 January 2022
Estimated completion	30 January 2022
Sites	1 location across Egypt

Drugs / interventions tested

i-PRF
Diode Laser

Conditions studied

Gingival Pigmentation — all drugs for Gingival Pigmentation →

Sponsor

Ain Shams University

Who can join

Adults 16 to 45, any sex, with Gingival Pigmentation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objectives of the present study are to: 1. Evaluate the effect of I-PRF injection following laser gingival depigmentation technique on the healing period as a primary objective. 2. Assess patient satisfaction following the procedure in terms of pain and esthetic outcome as a secondary objective.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Injectable platelet rich fibrin effect on laser depigmented gingiva: a clinical randomized controlled split mouth trial with histological assessment.
Ibrahim SSA, Mandil IA, Ezzatt OM. · · 2024 · cited 4× · PMID 38536994 · DOI 10.1590/1678-7757-2022-0307

Verify or expand the search:

Other trials of i-PRF

Trials testing the same drug.

NCT06886438 — Periapical Bleeding Versus PRF Techniques in Regenerative Endodontic Therapy: A Randomized Controlled Trial · NA · completed
NCT06073535 — The Use of Injectable-Platelet Rich Fibrin (i-PRF) in the Lower Third Molar Extraction · NA · unknown
NCT05916742 — Biofunctionalization of a Volume-stable Collagen Matrix (VCMX) for the Treatment of Single Gingival Recession · NA · unknown
NCT05640206 — Effect of Injectable Platelet-rich Fibrin on Disc Displacement Without Reduction · NA · completed
NCT04810923 — Application of Injectable Platelet-Rich Fibrin for the Treatment of Temporomandibular Joint Osteoarthritis · NA · completed

Other recruiting trials for Gingival Pigmentation

Currently open trials in the same condition.

NCT07359339 — Microneedling With Platelet Rich Plasma Versus Microneedling Alone For Gingival Depigmentation · NA · recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT05283668 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 17 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05283668.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing