NCT04652544 is a Phase 3 clinical trial of Cholecalciferol (Vitamin D3) in Spinal Cord Injuries, sponsored by Swiss Paraplegic Research, Nottwil.

Who is sponsoring NCT04652544?

NCT04652544 is sponsored by Swiss Paraplegic Research, Nottwil.

What drugs are being tested in NCT04652544?

Interventions in NCT04652544: Cholecalciferol (Vitamin D3), Placebo.

What condition does NCT04652544 study?

NCT04652544 studies Spinal Cord Injuries, Vitamin D Deficiency.

Is NCT04652544 still recruiting?

NCT04652544 is currently completed. Last updated 8 March 2024.

Last reviewed 2024-03-08 · How we verify

NCT04652544

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Vitamin D Supplementation in Individuals With a Chronic Spinal Cord Injury

Completed Phase 3 Last updated 8 March 2024

What this trial tests

Phase 3 trial testing Cholecalciferol (Vitamin D3) in Spinal Cord Injuries in 50 participants. Completed in 23 January 2024.

Timeline

19 May 2021

Primary endpoint
23 January 2024

23 January 2024

Quick facts

Lead sponsor	Swiss Paraplegic Research, Nottwil
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	50
Start date	19 May 2021
Primary completion	23 January 2024
Estimated completion	23 January 2024
Sites	1 location across Switzerland

Drugs / interventions tested

Cholecalciferol (Vitamin D3) — full drug profile →
Placebo

Conditions studied

Spinal Cord Injuries — all drugs for Spinal Cord Injuries →
Vitamin D Deficiency — all drugs for Vitamin D Deficiency →

Sponsor

Swiss Paraplegic Research, Nottwil — full company profile →

Who can join

Adults 18 to 60, any sex, with Spinal Cord Injuries or Vitamin D Deficiency. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The main objective of this placebo-controlled randomized double-blinded study is to investigate the effect of vitamin D supplementation on vitamin D status (25(OH)D concentration in the blood) among individuals with a chronic spinal cord injury (SCI). Further, the effects of vitamin D supplementation on several other parameters (e.g. bone density and mood) are investigated, which could reveal positive secondary effects of supplementation that are especially relevant for clinical practice.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Vitamin D supplementation in chronic spinal cord injury (VitD-SCI): study protocol for a randomised controlled trial.
Hertig-Godeschalk A, Brinkhof MWG, Scheel-Sailer A, Perret C, et al · · 2021 · cited 8× · PMID 34921084 · DOI 10.1136/bmjopen-2021-053951
No discernible effect of vitamin D supplementation on secondary outcomes in chronic spinal cord injury: Findings from a randomized controlled trial.
Hertig-Godeschalk A, Flueck JL, Scheel-Sailer A, Perret C, et al · · 2025 · PMID 41032389 · DOI 10.1080/10790268.2025.2557078

Verify or expand the search:

Other trials of Cholecalciferol (Vitamin D3)

Trials testing the same drug.

NCT03395171 — Vitamin D3 Supplementation and Stress Fracture Occurrence in High-Risk Collegiate Athletes · NA · completed

Other recruiting trials for Spinal Cord Injuries

Currently open trials in the same condition.

NCT07109804 — Cuneiform Nucleus (CnF) Deep Brain Stimulation for Gait Facilitation Following Spinal Cord Injury · NA · recruiting
NCT07472985 — Protocol for Rapid Onset of Mobilization in Patients With Traumatic Spinal Cord Injury II (PROMPT-SCI II) Trial · NA · recruiting
NCT07210411 — Acute and Chronic Repercussion of Spinal Cord Stimulation After Spinal Cord Injury · NA · recruiting
NCT07488793 — Remote Ischemic Conditioning for PwSCI · NA · recruiting
NCT07536386 — Self-balancing Personal Exoskeleton for SCI (WIP) · NA · recruiting

Other Swiss Paraplegic Research, Nottwil trials

Trials by the same sponsor.

NCT07456722 — Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia · not yet recruiting
NCT06905470 — The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation · NA · not yet recruiting
NCT07165353 — Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI · NA · recruiting
NCT06892080 — Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury/Disease - a Pilot Study · recruiting
NCT06633588 — Decolonization Efficacy of Polyhexanide vs. Mupirocin · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04652544 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Swiss Paraplegic Research, Nottwil
Last refreshed: 8 March 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04652544.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing