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NCT07456722: HEART_REMOD_AD
Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia
trial in Autonomic Dysreflexia in 48 participants. Not yet recruiting.
31 July 2028
Quick facts
| Lead sponsor | Swiss Paraplegic Research, Nottwil |
|---|---|
| Status | Not yet recruiting |
| Study type | OBSERVATIONAL |
| Enrollment | 48 |
| Start date | 1 May 2026 |
| Primary completion | 31 July 2028 |
| Estimated completion | 31 October 2028 |
| Sites | 1 location across Switzerland |
Conditions studied
- Autonomic Dysreflexia — all drugs for Autonomic Dysreflexia →
- Spinal Cord Injuries and Disorders (SCI/D) — all drugs for Spinal Cord Injuries and Disorders (SCI/D) →
- Cardiac Remodeling — all drugs for Cardiac Remodeling →
Sponsor
Swiss Paraplegic Research, Nottwil — full company profile →
Who can join
18 and older, any sex, with Autonomic Dysreflexia or Spinal Cord Injuries and Disorders (SCI/D). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history. The primary objective is to compare cardiac changes between 24 individuals with high-level SCI/D (above Th6) who have AD and 24 individuals with low-level SCI/D (below Th10) who do not have AD. A secondary objective examines how factors such as age, sex, injury duration, and physical activity are associated with cardiac remodeling. All 48 participants will undergo cardiac MRI as well as blood measurement of B-type natriuretic peptid to assess cardiac morphology and function. The findings could shed light on a potentially underestimated cardiovascular risk factor in the SCI/D population.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07456722
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Autonomic Dysreflexia
Currently open trials in the same condition.
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- NCT06211491 — Autonomic Dysreflexia in Spinal Cord Injuries: UDS Filling Speed Impact · recruiting
- NCT05351827 — Mild Intermittent Hypoxia: A Prophylactic for Autonomic Dysfunction in Individuals With Spinal Cord Injuries · NA · recruiting
- NCT04193709 — Recovery of Bladder and Sexual Function After Human Spinal Cord Injury · NA · recruiting
- NCT04493372 — Deciphering Preserved Autonomic Function After Spinal Cord Injury · NA · recruiting
Other Swiss Paraplegic Research, Nottwil trials
Trials by the same sponsor.
- NCT06905470 — The Effects of Eccentric Compared to Standard Strength Training in Primary Spinal Cord Injury Rehabilitation · NA · not yet recruiting
- NCT07165353 — Virtual Walking to Reduce Chronic Neuropathic Pain in Subjects With SCI · NA · recruiting
- NCT06892080 — Urine Incontinence Occurrence and Sexual Hormones in Women With Chronic Spinal Cord Injury/Disease - a Pilot Study · recruiting
- NCT06633588 — Decolonization Efficacy of Polyhexanide vs. Mupirocin · Phase 4 · recruiting
- NCT06710808 — VIRTUAL WALKING AND TRANSCRANIAL DIRECT CURRENT STIMULATION FOR CHRONIC NEUROPATHIC PAIN DUE TO SPINAL CORD INJURY · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07456722 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Swiss Paraplegic Research, Nottwil
- Last refreshed: 11 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07456722.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing