Last reviewed · How we verify
cholecalciferol (vitamin D3)
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function.
Cholecalciferol (vitamin D3) is converted in the body to its active form, calcitriol, which regulates calcium and phosphate homeostasis and modulates immune function. Used for Vitamin D deficiency, Hypocalcemia, Hypoparathyroidism.
At a glance
| Generic name | cholecalciferol (vitamin D3) |
|---|---|
| Also known as | vitamin D3, Vi-De 3® Monthly Dose |
| Sponsor | Medical University of South Carolina |
| Drug class | Vitamin D analog / Secosteroid |
| Target | Vitamin D receptor (VDR) |
| Modality | Small molecule |
| Therapeutic area | Endocrinology / Bone Health / Immunology |
| Phase | FDA-approved |
Mechanism of action
Vitamin D3 is a fat-soluble secosteroid that undergoes hydroxylation in the liver to 25-hydroxyvitamin D and then in the kidneys to the active metabolite 1,25-dihydroxyvitamin D (calcitriol). Calcitriol acts as a ligand for the vitamin D receptor (VDR), a nuclear receptor that regulates gene expression involved in calcium absorption, bone mineralization, and immune cell differentiation. Beyond skeletal health, vitamin D3 influences innate and adaptive immunity, cardiovascular function, and cellular proliferation.
Approved indications
- Vitamin D deficiency
- Hypocalcemia
- Hypoparathyroidism
- Osteomalacia
- Rickets
Common side effects
- Hypercalcemia
- Hypercalciuria
- Nausea
- Vomiting
- Constipation
- Weakness
Key clinical trials
- Pharmacokinetics, Pharmacodynamics, Safety and Tolerability Evaluation of CTAP101 Extended-release Capsules in Pediatric Participants (PHASE2)
- Effect of Tirzepatide and Bimagrumab on Body Composition, Insulin Sensitivity, and Bone in Adults With Obesity (PHASE2)
- Correlation Vitamin D Level to Endocrine Autoimmune Toxicity Due to Immune Checkpoint Inhibitors
- Acute Vitamin D Supplementation on Testosterone in Females (NA)
- Association Between Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency .
- PRESS -PAR: Early Detection and PREvention of Symptomatic postSurgical hypoPARathyroidism After Thyroid Surgery" (NA)
- Impact of Vitamin D Supplementation on the Rate of Pathologic Complete Response in Vitamin D Deficient Patients (PHASE2)
- Effect of the Consumption of Cookies Enriched With Plant Proteins and of a Vitamin D Supplement on the Progression of Sarcopenia in the Elderly (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- cholecalciferol (vitamin D3) CI brief — competitive landscape report
- cholecalciferol (vitamin D3) updates RSS · CI watch RSS
- Medical University of South Carolina portfolio CI