NCT04329364 (COHLAH) is a Phase 2, PHASE3 clinical trial of Laser Haemorrhoidoplasty (LAH) in Hemorrhoids, sponsored by Sengkang General Hospital.

Who is sponsoring NCT04329364?

NCT04329364 is sponsored by Sengkang General Hospital.

What drugs are being tested in NCT04329364?

Interventions in NCT04329364: Laser Haemorrhoidoplasty (LAH), Open milligan-morgan conventional haemorrhoidectomy.

What condition does NCT04329364 study?

NCT04329364 studies Hemorrhoids.

Is NCT04329364 still recruiting?

NCT04329364 is currently recruiting now. Last updated 22 April 2024.

Last reviewed 2024-04-22 · How we verify

NCT04329364: COHLAH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

RCT Comparing Conventional Haemorrhoidectomy With Laser Haemorrhoidoplasty

Recruiting now Phase 2, PHASE3 Last updated 22 April 2024

What this trial tests

Phase 2, PHASE3 trial testing Laser Haemorrhoidoplasty (LAH) in Hemorrhoids in 128 participants. Currently enrolling.

Timeline

1 October 2020

Primary endpoint
31 December 2024

30 June 2025

Quick facts

Lead sponsor	Sengkang General Hospital
Phase	Phase 2, PHASE3
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	128
Start date	1 October 2020
Primary completion	31 December 2024
Estimated completion	30 June 2025
Sites	1 location across Singapore

Drugs / interventions tested

Laser Haemorrhoidoplasty (LAH)
Open milligan-morgan conventional haemorrhoidectomy

Conditions studied

Hemorrhoids — all drugs for Hemorrhoids →

Sponsor

Sengkang General Hospital

Who can join

Adults 21 to 90, any sex, with Hemorrhoids. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Haemorrhoids or piles are the most common colorectal condition in the local population. Patients often present with bleeding with bowel movement or anal discomfort, both of which causes significant anxiety and stress. For symptomatic sizeable piles, the treatment of choice still remains the conventional open excision (COH). However, this technique carries with it a significant risk of bleeding and pain immediately after the operation, leading to some period of discomfort for the patients. The laser haemorrhoidoplasty procedure (LAH) has been shown in preliminary studies to have less pain, and less complications compared to COH. This study aims to directly compare these two techniques in a local Asian population. The investigators would be conducting a single-centre RCT simultaneously comparing the conventional open Milligan-Morgan haemorrhoidectomy (COH) and the laser haemorrhoidoplasty procedure (LAH) for the treatment of symptomatic grade ll-lV haemorrhoids. Primary outcomes will be post-operative pain while secondary outcomes include post-operative bleeding, readmission and/or reoperations, haemorrhoid-related quality of life (QoL) results and recurrence of symptoms up to a year post procedure

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Study Protocol for the Use of Conventional Open Haemorrhoidectomy versus Laser Haemorrhoidoplasty in the Treatment of Symptomatic Haemorrhoids: A Randomized Controlled Trial.
Koh FH, Foo FJ, Ho L, Sivarajah SS, et al · · 2020 · cited 4× · PMID 33631763 · DOI 10.1159/000513844
Latest Research Trends on the Management of Hemorrhoids.
Kang SI. · · 2025 · cited 3× · PMID 40302863 · DOI 10.23922/jarc.2024-090

Verify or expand the search:

Other recruiting trials for Hemorrhoids

Currently open trials in the same condition.

NCT07350460 — PUSHES (Pudendal Block Versus Sacral ESP Hemorrhoidectomy Study) · NA · recruiting
NCT07317492 — HEMOVAR Study on Hemorrhoids and Varicose Veins · recruiting
NCT05782010 — SCI-Pex Study - Safety and Performance of PexyEazy®, a Device for Treatment of Hemorrhoids · NA · recruiting
NCT05697562 — Evaluation of Superior Rectal Arterial Embolization in Hemorrhoidal Disease · NA · recruiting
NCT03972956 — Samples Procurement for Colorectal Cancer, Gastric Cancer, and Non-malignant Disease · recruiting

Other Sengkang General Hospital trials

Trials by the same sponsor.

NCT06980402 — Post-discharge Monitoring Initiative on Outcomes of Post-surgical Patients · NA · not yet recruiting
NCT06708741 — Regime for Vitamin D Maintenance in Post-Operative Patients · Phase 3 · not yet recruiting
NCT06363253 — Pilot Study of the Human Metagenome in Metabolic Diseases · recruiting
NCT07477561 — Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-I · NA · recruiting
NCT05822895 — Review of the Impact of a Computer-aided Real-time Polyp Detection System on Adult Colonoscopy · unknown

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04329364 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Sengkang General Hospital
Last refreshed: 22 April 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04329364.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing