NCT07477561: INFINITY-ICOPE

Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore

Recruiting now NA Last updated 17 April 2026

What this trial tests

NA trial testing INFINITY-ICOPE programme in Frailty in Older Adults in 600 participants. Currently enrolling.

Timeline

17 July 2023

Primary endpoint
30 June 2027

15 January 2028

Quick facts

Lead sponsor	Sengkang General Hospital
Phase	NA
Status	Recruiting now
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	none
Primary purpose	health services research
Enrollment	600
Start date	17 July 2023
Primary completion	30 June 2027
Estimated completion	15 January 2028
Sites	1 location across Singapore

Drugs / interventions tested

• INFINITY-ICOPE programme

Conditions studied

• Frailty in Older Adults — all drugs for Frailty in Older Adults →
• Intrinsic Capacity — all drugs for Intrinsic Capacity →
• Age-related Functional Decline — all drugs for Age-related Functional Decline →
• Healthy Ageing — all drugs for Healthy Ageing →

Sponsor

Sengkang General Hospital

Who can join

60 and older, any sex, with Frailty in Older Adults or Intrinsic Capacity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early identification and targeted interventions can improve health outcomes and support healthy ageing. The main questions it aims to answer are:

* Can combined frailty and intrinsic capacity screening with targeted interventions prevent or reduce functional decline in older adults, as measured by changes in life space mobility?
* Will at least 80% of screened older adults adhere to recommended care pathways and interventions?
* Can this screening and intervention programme demonstrate sustainability through continued community participation and recruitment of new partner organizations beyond the initial implementation phase? The investigators will compare an intervention group (receiving immediate assessment and clinical referrals based on identified needs) to a wait-list control group (receiving the same interventions 12 months later) to see if early intervention leads to better health outcomes and quality of life.

Participants will:

* Attend 4 study visits over 2 years (at 6-monthly intervals in the first year, with final assessment at end of year 2), each lasting up to 2 hours.
* Undergo comprehensive screening assessments including mobility, cognition, mental health, hearing, vision, and nutritional status.
* Receive 2 follow-up phone calls at 3-month and 9-month intervals to monitor progress.
* If in the intervention group: receive personalized referrals for further care (which may include comprehensive geriatric assessment, primary care reviews, rehabilitation, or dietitian consultations) and guidance on using a mobile health monitoring application.
* If in the wait-list control group: receive the same interventions after their 3rd study visit (12 months later).

Publications & conference data

No peer-reviewed publications indexed yet for this trial.