Last reviewed · How we verify
NCT06708741: D-ECISIVE
Regime for Vitamin D Maintenance in Post-Operative Patients
Phase 3 trial testing Vitamin D in Sarcopenia in 100 participants. Not yet recruiting.
31 December 2025
Quick facts
| Lead sponsor | Sengkang General Hospital |
|---|---|
| Phase | Phase 3 |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | prevention |
| Enrollment | 100 |
| Start date | 1 January 2025 |
| Primary completion | 31 December 2025 |
| Estimated completion | 30 June 2026 |
| Sites | 1 location across Singapore |
Drugs / interventions tested
- Vitamin D
Conditions studied
- Sarcopenia — all drugs for Sarcopenia →
Sponsor
Sengkang General Hospital
Who can join
Adults 21 to 65, any sex, with Sarcopenia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Vitamin D plays a significant part calcium and phosphate haemostasis, thus, intrinsically critical for bone health. Increasing evidence also reveal that insufficient serum vitamin D levels also result in poor muscle health with such individuals having a compromised muscle building potential (4 times slower muscle building). Muscle health is a critical component of a post-surgical patient recovery, with impaired muscle function leading to reduced functional ability, resulting in a poorer quality of life. Poor muscle health also has negative repercussion on survivability, with reduced overall, and disease-specific survival, especially shown in cancer patients. Thus, maintenance of vitamin D levels post-surgery may be more critical than previously thought.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
The Role of Vitamin D Supplementation in Enhancing Muscle Strength Post-Surgery: A Systemic Review.
Wang JJ, Quak GS, Lee HB, Foo LX, et al · · 2025 · cited 3× · PMID 40362819 · DOI 10.3390/nu17091512 -
Sarcopenia and Muscle Aging: Updated Insights into Molecular Mechanisms and Translational Therapeutics.
Nguyen TT, Dao T, Nguyen HT, Park JH, et al · · 2026 · cited 1× · PMID 41674227 · DOI 10.3803/enm.2025.2656
Verify or expand the search:
- PubMed search for NCT06708741
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Vitamin D
Trials testing the same drug.
- NCT07366086 — Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta · Phase 3 · recruiting
- NCT07458815 — Vitamin D for Acute Intracerebral Hemorrhage · NA · not yet recruiting
- NCT07491965 — Association Between Benign Paroxysmal Positional Vertigo and Vitamin D Deficiency . · not yet recruiting
- NCT07400757 — Statin and Vitamin D Treatment in Patients With Thyroid Eye Disease · NA · not yet recruiting
- NCT07293910 — Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Py · Phase 2 · recruiting
Other recruiting trials for Sarcopenia
Currently open trials in the same condition.
- NCT07500376 — Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery · recruiting
- NCT07456956 — HIIT vs MCIT for Stroke-Related Sarcopenia in Ischemic Stroke · NA · recruiting
- NCT07398495 — Multimodal Training Effects in Middle-Aged and Older Adults With Diabetic Sarcopenia · NA · recruiting
- NCT07494916 — Effects of Functional Task Training on Muscle Health and Function in Older Adults With Sarcopenia · NA · active not recruiting
- NCT07426159 — AI-Guided Sarcopenia Risk Assessment and Detection · NA · active not recruiting
Other Sengkang General Hospital trials
Trials by the same sponsor.
- NCT06980402 — Post-discharge Monitoring Initiative on Outcomes of Post-surgical Patients · NA · not yet recruiting
- NCT06363253 — Pilot Study of the Human Metagenome in Metabolic Diseases · recruiting
- NCT07477561 — Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-I · NA · recruiting
- NCT05822895 — Review of the Impact of a Computer-aided Real-time Polyp Detection System on Adult Colonoscopy · unknown
- NCT05569304 — Endoscopic Sleeve Gastroplasty Versus GLP-1 Analogue for Class 1 and 2 Obesity Study · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06708741 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Sengkang General Hospital
- Last refreshed: 27 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06708741.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing