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NCT03754777: MERES
Modified Enhanced Recovery Program in Emergency Surgery (MERES)
NA trial testing Laparoscopic appendectomy in Acute Appendicitis in 122 participants. Completed in 1 February 2018.
1 December 2017
Quick facts
| Lead sponsor | Pirogov Russian National Research Medical University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 122 |
| Start date | 1 July 2017 |
| Primary completion | 1 December 2017 |
| Estimated completion | 1 February 2018 |
| Sites | 1 location across Russia |
Drugs / interventions tested
- Laparoscopic appendectomy
Conditions studied
- Acute Appendicitis — all drugs for Acute Appendicitis →
- Acute Appendicitis With Rupture — all drugs for Acute Appendicitis With Rupture →
- Acute Appendicitis With Peritonitis — all drugs for Acute Appendicitis With Peritonitis →
- Acute Appendicitis Without Peritonitis — all drugs for Acute Appendicitis Without Peritonitis →
Sponsor
Pirogov Russian National Research Medical University
Who can join
18 and older, any sex, with Acute Appendicitis or Acute Appendicitis With Rupture. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay. Almost 10% of patients develop postoperative complications. Enhanced recovery after surgery (ERAS) program has proven its effectiveness in elective surgery and can theoretically improve outcomes of LA. To date there is no ERAS program for LA. The aim of the study was to investigate the safety and efficacy of a modified ERAS protocol in LA.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Evaluation of enhanced recovery after surgery program components implemented in laparoscopic appendectomy: prospective randomized clinical study.
Nechay T, Sazhin A, Titkova S, Tyagunov A, et al · · 2020 · cited 14× · PMID 32612104 · DOI 10.1038/s41598-020-67591-5 -
[Appendectomy technique: paradigm shift or a well-forgotten old one? The role of mesoappendectomy in prevention of infectious intra-abdominal complications (announcement of RCT)].
Sazhin AV, Nechay TV, Titkova SM, Petukhov VA, et al · · 2020 · cited 1× · PMID 33047586 · DOI 10.17116/hirurgia202010149
Verify or expand the search:
- PubMed search for NCT03754777
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Laparoscopic appendectomy
Trials testing the same drug.
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- NCT04519086 — The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30 · NA · suspended
- NCT04755179 — Identification of the Optimal Treatment Strategy for Complex Appendicitis in the Pediatric Population · completed
- NCT03912714 — COlonic Salvage by Therapeutic Appendectomy. · NA · completed
- NCT04895163 — Acute Appendicitis in Foreign Workers of Northern Israel · completed
Other recruiting trials for Acute Appendicitis
Currently open trials in the same condition.
- NCT07496723 — Comparison of Diagnostic Methods in Patients Operated for Suspected Appendicitis · recruiting
- NCT07008092 — Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children · recruiting
- NCT07492329 — Antibiotics vs Surgery in Acute Appendicitis · NA · active not recruiting
- NCT06563349 — Magnesium Sulfate in Children Undergoing Laparoscopic Appendectomy · Phase 4 · recruiting
- NCT03236961 — Optimizing the Antibiotic Treatment of Uncomplicated Acute Appendicitis · NA · active not recruiting
Other Pirogov Russian National Research Medical University trials
Trials by the same sponsor.
- NCT07449728 — The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression · NA · recruiting
- NCT07363603 — Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders. · Phase 1, PHASE2 · recruiting
- NCT07083986 — Carotid Endarterectomy Versus Stenting in Patients With Acute Stage of Ischemic Stroke. · NA · enrolling by invitation
- NCT06766968 — Prolonged Compression Following Foam Sclerotherapy · NA · active not recruiting
- NCT06753786 — Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03754777 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pirogov Russian National Research Medical University
- Last refreshed: 27 November 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03754777.
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