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NCT07449728: LACROSS-VVP
The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression
NA trial testing Laser crossectomy on 1470 nm in Varicose Veins in 400 participants. Currently enrolling.
20 January 2028
Quick facts
| Lead sponsor | Pirogov Russian National Research Medical University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 400 |
| Start date | 20 January 2026 |
| Primary completion | 20 January 2028 |
| Estimated completion | 20 January 2029 |
| Sites | 1 location across Russia |
Drugs / interventions tested
- Laser crossectomy on 1470 nm
- Laser crossectomy on 1940 nm
- Standard EVLT with a stump
Conditions studied
- Varicose Veins — all drugs for Varicose Veins →
- Chronic Venous Insufficiency — all drugs for Chronic Venous Insufficiency →
Sponsor
Pirogov Russian National Research Medical University
Who can join
18 and older, any sex, with Varicose Veins or Chronic Venous Insufficiency. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Technically successful laser crossectomy will reduce the risk of reflux recurrence at the sapheno-femoral junction without increasing the risk of endovenous heat-induced thrombosis, which may positively impact the likelihood of ultrasound- or clinical-recurrence of varicose veins. Similar technical efficacy is expected for laser crossectomy at 1940 nm and 1470 nm. A possible advantage of the 1940 nm wavelength in terms of postoperative pain intensity and the risk of adverse events cannot be ruled out.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07449728
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Varicose Veins
Currently open trials in the same condition.
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- NCT05735639 — THRomboprophylaxis in Individuals Undergoing Superficial endoVEnous Treatment (THRIVE) · Phase 4 · recruiting
- NCT05410912 — Varicose Vein in Patients Under the Age of 40 · active not recruiting
- NCT04231942 — Elastic Compression Stockings and Varicose Veins Recurrence · NA · active not recruiting
- NCT03416413 — Study of Foam Sclerotherapy Versus Ambulatory Phlebectomy · Phase 4 · recruiting
Other Pirogov Russian National Research Medical University trials
Trials by the same sponsor.
- NCT07363603 — Tianasen (ASO-GNAO1) for GNAO1-Encephalopathy With Epilepsy and Movement Disorders. · Phase 1, PHASE2 · recruiting
- NCT07083986 — Carotid Endarterectomy Versus Stenting in Patients With Acute Stage of Ischemic Stroke. · NA · enrolling by invitation
- NCT06766968 — Prolonged Compression Following Foam Sclerotherapy · NA · active not recruiting
- NCT06753786 — Timing of Venous Thromboembolism Prophylaxis in Patients With Hypertensive Intracerebral Hemorrhage · NA · recruiting
- NCT06175715 — General Versus Regional Anesthesia for Carotid Endarterectomy at Acute Ischemic Stroke Trial · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07449728 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pirogov Russian National Research Medical University
- Last refreshed: 4 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07449728.
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