NCT04519086 (OPTICAP>30) is a NA clinical trial of Low-dose CT in Appendicitis, sponsored by Turku University Hospital.

Who is sponsoring NCT04519086?

NCT04519086 is sponsored by Turku University Hospital.

What drugs are being tested in NCT04519086?

Interventions in NCT04519086: Low-dose CT, Laparoscopic appendectomy.

What condition does NCT04519086 study?

NCT04519086 studies Appendicitis, Other and Unspecified Acute Appendicitis, Acute Disease, Gastrointestinal Disease, Intra-abdominal Infection.

Is NCT04519086 still recruiting?

NCT04519086 is currently suspended. Last updated 25 February 2022.

Last reviewed 2022-02-25 · How we verify

NCT04519086: OPTICAP>30

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Optimization of a Low-dose CT Protocol in Patients With Suspected Uncomplicated Acute Appendicitis and BMI >30

Suspended NA Last updated 25 February 2022

What this trial tests

NA trial testing Low-dose CT in Appendicitis in 30 participants. Suspended.

Timeline

4 November 2020

Primary endpoint
17 November 2021

17 November 2023

Quick facts

Lead sponsor	Turku University Hospital
Phase	NA
Status	Suspended
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	30
Start date	4 November 2020
Primary completion	17 November 2021
Estimated completion	17 November 2023
Sites	1 location across Finland

Drugs / interventions tested

Low-dose CT
Laparoscopic appendectomy

Conditions studied

Appendicitis — all drugs for Appendicitis →
Other and Unspecified Acute Appendicitis — all drugs for Other and Unspecified Acute Appendicitis →
Acute Disease — all drugs for Acute Disease →
Gastrointestinal Disease — all drugs for Gastrointestinal Disease →

Sponsor

Turku University Hospital

Who can join

Adults 18 to 60, any sex, with Appendicitis or Other and Unspecified Acute Appendicitis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study focuses on the use of contrast enhanced low-dose CT imaging as a modality to differentiate between uncomplicated and complicated acute appendicitis. Accurate differential diagnosis allows the assessment of all available treatment options. Complicated acute appendicitis requires emergency appendectomy, while uncomplicated acute appendicitis can be safely and efficiently treated with antibiotics in the majority of patients. Our study group already published the results of the initial OPTICAP trial enrolling patients with BMI under 30 showing similar accuracy between the low-dose and the stadard dose CT, but a significant dose reduction associated with the low-dose CT. All patients will undergo both imaging protocols as the standard CT is also optimized for a low as possible radiation dosage and imaging sequence per patient is randomized due to the optimization of contrast media injection timing. All patients participating in this study will be treated operatively with a laparoscopic appendectomy to obtain histological confirmation for the diagnosis to evaluate the accuracy of the CT imaging. The aim of this study is to optimize a well-performing low-dose CT imaging protocol to use in the diagnosis of uncomplicated acute appendicitis in patients with body mass index over 30 kg/m2.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other recruiting trials for Appendicitis

Currently open trials in the same condition.

NCT07115303 — Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure · NA · recruiting
NCT06395636 — Early Detection of Infection Using the Fitbit in Pediatric Surgical Patients · NA · recruiting
NCT07049965 — Comparative Study of Harmonic Scalpel vs. Suture Ligation for Appendix Base During Laparoscopic Appendectomy · NA · active not recruiting
NCT07478029 — Clinical Study of PEG Bowel Preparation in Appendectomy Patients · recruiting
NCT06177418 — Transumbilical Laparoscopic Appendectomy · NA · recruiting

Other Turku University Hospital trials

Trials by the same sponsor.

NCT07488494 — Effective Implementation of the Physical Activity and Motor Skills Intervention for 3-6-year-old Children With Cancer (E · NA · not yet recruiting
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NCT07306000 — Pilot Study: Effects of CCP Intervention on NICU Environment and Preterm Infants Development · NA · recruiting
NCT07272824 — Usability Study of Gestational and Postpartum Weight Management Program · recruiting
NCT07310472 — Administration of the Nasal Influenza Vaccine to Children in Daycare or at a Healthcare Facility · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04519086 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Turku University Hospital
Last refreshed: 25 February 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04519086.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing