NCT03491644 (TRAUMOX) is a Phase 4 clinical trial of Titrated Oxygen in Trauma, sponsored by Rigshospitalet, Denmark.

Who is sponsoring NCT03491644?

NCT03491644 is sponsored by Rigshospitalet, Denmark.

What drugs are being tested in NCT03491644?

Interventions in NCT03491644: Titrated Oxygen, Liberal Oxygen.

What condition does NCT03491644 study?

NCT03491644 studies Trauma, Wounds and Injuries.

Is NCT03491644 still recruiting?

NCT03491644 is currently completed. Last updated 14 August 2018.

Last reviewed 2018-08-14 · How we verify

NCT03491644: TRAUMOX

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Restrictive vs. Liberal Oxygen Therapy for Trauma Patients

Completed Phase 4 Last updated 14 August 2018

What this trial tests

Phase 4 trial testing Titrated Oxygen in Trauma in 41 participants. Completed in 2 July 2018.

Timeline

3 April 2018

Primary endpoint
2 July 2018

2 July 2018

Quick facts

Lead sponsor	Rigshospitalet, Denmark
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	41
Start date	3 April 2018
Primary completion	2 July 2018
Estimated completion	2 July 2018
Sites	1 location across Denmark

Drugs / interventions tested

Titrated Oxygen — full drug profile →
Liberal Oxygen — full drug profile →

Conditions studied

Trauma — all drugs for Trauma →
Wounds and Injuries — all drugs for Wounds and Injuries →

Sponsor

Rigshospitalet, Denmark

Who can join

18 and older, any sex, with Trauma or Wounds and Injuries. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of this trial is to investigate whether treatment with oxygen in the early phases after a trauma plays a role in recovery.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Comparing restrictive versus liberal oxygen strategies for trauma patients - the TRAUMOX2 trial: protocol for a randomised clinical trial.
Baekgaard J, Arleth T, Siersma V, Hinkelbein J, et al · · 2022 · cited 6× · PMID 36344005 · DOI 10.1136/bmjopen-2022-064047

Verify or expand the search:

Other trials of Titrated Oxygen

Trials testing the same drug.

NCT07375173 — ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound · NA · not yet recruiting
NCT05703919 — Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease · Phase 4 · recruiting

Other recruiting trials for Trauma

Currently open trials in the same condition.

NCT07290634 — Comparative Outcomes of PCC and Recombinant Activated Factor VIIa in Trauma-Associated Massive Transfusion · recruiting
NCT07485231 — Nitric Oxide (NO) and Endothelial Dysfunction in Women With PTSD · NA · recruiting
NCT07473336 — The Effectiveness of RAPID-Based Psychological First Aid Training · NA · active not recruiting
NCT07278505 — Study of Cannabidiol and Neuroimaging on Stress · Phase 1, PHASE2 · recruiting
NCT02880163 — REVIVE: Reducing Exsanguination Via In-Vivo Expandable Foam · NA · recruiting

Other Rigshospitalet, Denmark trials

Trials by the same sponsor.

NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03491644 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
Last refreshed: 14 August 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03491644.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing