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Liberal oxygen
Liberal oxygen therapy increases inspired oxygen concentration to elevate blood oxygen levels and tissue oxygenation.
Liberal oxygen therapy increases inspired oxygen concentration to elevate blood oxygen levels and tissue oxygenation. Used for Perioperative oxygen supplementation, Critical illness with hypoxemia.
At a glance
| Generic name | Liberal oxygen |
|---|---|
| Sponsor | Rigshospitalet, Denmark |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Perioperative Medicine |
| Phase | FDA-approved |
Mechanism of action
Liberal oxygen administration delivers higher concentrations of oxygen to patients, increasing arterial oxygen partial pressure (PaO2) and oxygen saturation. This approach aims to maximize oxygen delivery to tissues, though evidence suggests potential risks including hyperoxia-induced oxidative stress and increased mortality in certain patient populations.
Approved indications
- Hypoxemia management in critically ill patients
- Perioperative oxygenation
Common side effects
- Hyperoxia-induced oxidative stress
- Increased mortality (in certain populations)
- Absorption atelectasis
- Oxygen toxicity
Key clinical trials
- Oxygen Targets in Acute Heart Failure With Pulmonary Congestion (PHASE2, PHASE3)
- PeRiOperative Medicine Platform Trial (PHASE4)
- Oxygen Extraction-guided Transfusion (NA)
- The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia (NA)
- Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery (PHASE3)
- Oxy-PICU Neurodevelopmental Follow-up Study
- Restrictive Vs. Liberal Oxygen in Trauma (PHASE4)
- GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |