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Titrated Oxygen
Titrated oxygen therapy increases arterial oxygen partial pressure to improve tissue oxygenation in hypoxemic patients.
Titrated oxygen therapy increases arterial oxygen partial pressure to improve tissue oxygenation in hypoxemic patients. Used for Hypoxemia in COPD exacerbation, Acute respiratory failure, Pneumonia with hypoxemia.
At a glance
| Generic name | Titrated Oxygen |
|---|---|
| Also known as | Oxygen titration to SpO₂ 88-92% and compressed atmospheric air as nebulizer driver |
| Sponsor | Rigshospitalet, Denmark |
| Modality | Small molecule |
| Therapeutic area | Respiratory/Critical Care |
| Phase | FDA-approved |
Mechanism of action
Titrated oxygen involves the controlled, gradual administration of supplemental oxygen adjusted to maintain target oxygen saturation levels (typically SpO2 88-92% in COPD, 94-98% in other conditions). This approach prevents both hypoxemia and hyperoxia-related complications such as CO2 retention in COPD patients or oxygen toxicity. The titration is guided by pulse oximetry or arterial blood gas monitoring to optimize therapeutic benefit while minimizing adverse effects.
Approved indications
- Hypoxemia in COPD exacerbation
- Acute respiratory failure
- Pneumonia with hypoxemia
- Post-operative hypoxemia
Common side effects
- Hypercapnia (CO2 retention) in COPD patients
- Oxygen toxicity with prolonged high-concentration exposure
- Drying of airways and mucous membranes
- Absorption atelectasis
Key clinical trials
- Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study (NA)
- HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT (NA)
- Comparing Mortality for Low vs High Peripheral Oxygen Saturation in COPD-patients With Acute Exacerbation (PHASE4)
- Siplizumab for Sickle Cell Disease Transplant (PHASE1, PHASE2)
- Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery (NA)
- Epoprostenol Plus Conventional Therapy in COld and Frostbite Injury (ECCO) (PHASE4)
- Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial). (NA)
- Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |