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The titration is guided by pulse oximetry or arterial blood gas monitoring to optimize therapeutic benefit while minimizing adverse effects.","oneSentence":"Titrated oxygen therapy increases arterial oxygen partial pressure to improve tissue oxygenation in hypoxemic patients.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:12:51.952Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hypoxemia in COPD exacerbation"},{"name":"Acute respiratory failure"},{"name":"Pneumonia with hypoxemia"},{"name":"Post-operative hypoxemia"}]},"trialDetails":[{"nctId":"NCT06996665","phase":"NA","title":"Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study","status":"RECRUITING","sponsor":"Sir Run Run Shaw Hospital","startDate":"2025-06-01","conditions":"Respiratory Failure","enrollment":100},{"nctId":"NCT05078034","phase":"NA","title":"HNFO With or Without Helmet NIV for Oxygenation Support in Acute 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