NCT03094715 (Tension) is a NA clinical trial of Thrombectomy in Stroke, Acute, sponsored by University Hospital Heidelberg.

Who is sponsoring NCT03094715?

NCT03094715 is sponsored by University Hospital Heidelberg.

What drugs are being tested in NCT03094715?

Interventions in NCT03094715: Thrombectomy, Best medical care.

What condition does NCT03094715 study?

NCT03094715 studies Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain.

Is NCT03094715 still recruiting?

NCT03094715 is currently terminated. Last updated 5 December 2023.

Last reviewed 2023-12-05 · How we verify

NCT03094715: Tension

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window

Terminated NA Last updated 5 December 2023

What this trial tests

NA trial testing Thrombectomy in Stroke, Acute in 253 participants. Terminated before completion.

Timeline

20 June 2018

Primary endpoint
31 May 2023

15 November 2023

Quick facts

Lead sponsor	University Hospital Heidelberg
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	253
Start date	20 June 2018
Primary completion	31 May 2023
Estimated completion	15 November 2023
Sites	42 locations across Denmark, France, Slovakia, Austria, Germany, Norway, Canada, Switzerland

Drugs / interventions tested

Thrombectomy
Best medical care — full drug profile →

Conditions studied

Stroke, Acute — all drugs for Stroke, Acute →
Cerebral Stroke — all drugs for Cerebral Stroke →
Cerebrovascular Stroke — all drugs for Cerebrovascular Stroke →
Apoplexy; Brain — all drugs for Apoplexy; Brain →

Sponsor

University Hospital Heidelberg

Who can join

18 and older, any sex, with Stroke, Acute or Cerebral Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

TENSION (Efficacy and safety of ThrombEctomy iN Stroke with extended leSION and extended time window) is a prospective, open label, blinded endpoint (PROBE), European two-arm, randomized, controlled, post-market study to compare the safety and effectiveness of endovascular thrombectomy as compared to best medical care alone in the treatment of acute ischemic stroke patients with extended stroke lesions defined by an Alberta Stroke Program Early CT Score (ASPECTS) score of 3-5 and in an extended time window (up to 12 hours or unknown time of symptom onset). Up to 665 subjects will be randomized. Primary endpoint will be functional outcome assessed by the modified Rankin scale at 90 days post-stroke ("mRS shift analysis"). By this, TENSION will provide evidence of efficacy and safety of thrombectomy in an acute stroke population with uncertain benefit of endovascular stroke treatment.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial.
Bendszus M, Fiehler J, Subtil F, Bonekamp S, et al · · 2023 · cited 360× · PMID 37837989 · DOI 10.1016/s0140-6736(23)02032-9
Pathophysiology of Blood-Brain Barrier Permeability Throughout the Different Stages of Ischemic Stroke and Its Implication on Hemorrhagic Transformation and Recovery.
Bernardo-Castro S, Sousa JA, Brás A, Cecília C, et al · · 2020 · cited 258× · PMID 33362697 · DOI 10.3389/fneur.2020.594672
Mechanical Thrombectomy in Ischemic Stroke Patients With Alberta Stroke Program Early Computed Tomography Score 0-5.
Kaesmacher J, Chaloulos-Iakovidis P, Panos L, Mordasini P, et al · · 2019 · cited 93× · PMID 30827193 · DOI 10.1161/strokeaha.118.023465
Mechanical Thrombectomy for Large Ischemic Stroke: A Systematic Review and Meta-analysis.
Li Q, Abdalkader M, Siegler JE, Yaghi S, et al · · 2023 · cited 89× · PMID 37277200 · DOI 10.1212/wnl.0000000000207536
Acute ischaemic stroke: recent advances in reperfusion treatment.
Widimsky P, Snyder K, Sulzenko J, Hopkins LN, et al · · 2023 · cited 82× · PMID 36477996 · DOI 10.1093/eurheartj/ehac684
A randomized controlled trial to test efficacy and safety of thrombectomy in stroke with extended lesion and extended time window.
Bendszus M, Bonekamp S, Berge E, Boutitie F, et al · · 2019 · cited 69× · PMID 30156479 · DOI 10.1177/1747493018798558
Intracranial Hemorrhage After Reperfusion Therapies in Acute Ischemic Stroke Patients.
Maïer B, Desilles JP, Mazighi M. · · 2020 · cited 64× · PMID 33362701 · DOI 10.3389/fneur.2020.599908
Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis.
Ng FC, Yassi N, Sharma G, Brown SB, et al · · 2021 · cited 62× · PMID 34384229 · DOI 10.1161/strokeaha.120.033246

Verify or expand the search:

Other trials of Thrombectomy

Trials testing the same drug.

NCT06654453 — The Thrombus Aspiration During PCI After Thrombolysis in STEMI · NA · recruiting
NCT06375174 — PRECISE (PERFUSION IMAGING TO IDENTIFY POSTERIOR CIRCULATION CANDIDATES FOR THROMBECTOMY) · active not recruiting
NCT03903536 — Thrombosed External Hemorrhoids: Comparison of the Thrombectomy and Local Excision Procedures in Terms of Results and Ou · completed
NCT04240470 — Endovascular Stroke Treatment Only (ESTO) Trial · NA · completed
NCT04256096 — Randomization of Endovascular Treatment in Acute Ischemic Stroke in the Extended Time Window · Phase 3 · unknown

Other recruiting trials for Stroke, Acute

Currently open trials in the same condition.

NCT06825897 — Delay AvoIding Primary Evaluation for ThRombectomy of Acute StrokE Patients With Large Vessel OCclusion in the Angiograp · NA · recruiting
NCT06658197 — Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke · Phase 3 · recruiting
NCT07253870 — Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients · NA · recruiting
NCT06941753 — Off-script Diagnosis & Differential Diagnosis (D&D) Training and Residents' Stroke Knowledge · NA · recruiting
NCT06123650 — Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia. · NA · recruiting

Other University Hospital Heidelberg trials

Trials by the same sponsor.

NCT07388147 — Exercise Therapy for Multiple Myeloma Patients · NA · not yet recruiting
NCT07348874 — Predictive Accuracy of Machine Perfusion for Kidney Transplant Outcomes in Germany · not yet recruiting
NCT07181928 — Is Mentalization-based Therapy More Effective Than Treatment-as-usual for Adolescents With Dissocial Disorders? · NA · not yet recruiting
NCT06954623 — Partial Breast Re-irradiation for Breast Cancer · NA · recruiting
NCT06913010 — DV 100 as a Framework for the Hospital Incident Command System · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT03094715 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital Heidelberg
Last refreshed: 5 December 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT03094715.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing