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NCT02727296: VAPOR-2
Volatile Anesthetic Protection Of Renal Transplants 2
Phase 4 trial testing sevoflurane in Delayed Graft Function in 488 participants. Completed in 31 January 2025.
30 January 2025
Quick facts
| Lead sponsor | University Medical Center Groningen |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 488 |
| Start date | 1 April 2017 |
| Primary completion | 30 January 2025 |
| Estimated completion | 31 January 2025 |
| Sites | 5 locations across Denmark, Netherlands, Spain, Norway |
Drugs / interventions tested
- sevoflurane — full drug profile →
- propofol (Propofol) — full drug profile →
Conditions studied
- Delayed Graft Function — all drugs for Delayed Graft Function →
- Renal Outcome After Kidney Transplantation — all drugs for Renal Outcome After Kidney Transplantation →
- Acute Rejection (AR) of Transplanted Kidney — all drugs for Acute Rejection (AR) of Transplanted Kidney →
- Graft Survival — all drugs for Graft Survival →
Sponsor
University Medical Center Groningen
Who can join
18 and older, any sex, with Delayed Graft Function or Renal Outcome After Kidney Transplantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.
Nieuwenhuijs-Moeke GJ, Bosch DJ, Leuvenink HGD. · · 2021 · cited 12× · PMID 33800423 · DOI 10.3390/ijms22052727 -
Systemic and Renal Dynamics of Free Sulfhydryl Groups during Living Donor Kidney Transplantation.
Spraakman NA, Coester AM, Bourgonje AR, Nieuwenhuijs VB, et al · · 2022 · cited 3× · PMID 36077183 · DOI 10.3390/ijms23179789 -
Propofol-based versus sevoflurane-based anaesthesia for deceased donor kidney transplantation: the VAPOR-2 study protocol for an international multicentre randomised controlled trial.
Huisman GJJ, Berger SP, Thyrrestrup PS, Hausken J, et al · · 2025 · cited 1× · PMID 40897490 · DOI 10.1136/bmjopen-2025-098965
Verify or expand the search:
- PubMed search for NCT02727296
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of sevoflurane
Trials testing the same drug.
- NCT06396468 — Sevoflurane and Intravenous Anesthesia in Hypospadias Repair · NA · unknown
- NCT05822817 — Comparison of Postoperative Recovery of Sevoflurane and Propofol After Transsphenoidal Surgery · Phase 4 · completed
- NCT05442905 — Quadratus Lumborum Versus Transversus Abdominis Plane Block Versus Caudal Block for Postoperative Analgesia After Pediat · NA · unknown
- NCT03987529 — Effects of Volatile and Intravenous Anesthetics on Pupillary Function · unknown
- NCT04426552 — Dexmedetomidine Versus Sevoflurane in Children With Anticipated Difficult Intubation · Phase 2 · unknown
Other recruiting trials for Delayed Graft Function
Currently open trials in the same condition.
- NCT07275632 — The Effects of Vonoprazan Fumarate on DGF Incidence in DD Kidney Transplant Recipients · Phase 1, PHASE2 · recruiting
- NCT06830798 — Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Admin · Phase 3 · recruiting
- NCT06367205 — Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations · NA · recruiting
- NCT05907096 — ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function · Phase 2 · active not recruiting
- NCT05430620 — Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys · Phase 3 · recruiting
Other University Medical Center Groningen trials
Trials by the same sponsor.
- NCT06647602 — Thyroid Hormone Replacement After Radio Iodine: Value and Efficacy · not yet recruiting
- NCT06809946 — Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy · Phase 2 · not yet recruiting
- NCT07527390 — CANagliflozin In DIALysis Patients · Phase 4 · not yet recruiting
- NCT07439237 — Implant-supported Maxillary Overdentures; a 15-years Evaluation · not yet recruiting
- NCT07275437 — Effectiveness and Safety of Uptitration of Guideline Directed MEdical Therapy in Heart Failure With Reduced Ejection Fra · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02727296 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Center Groningen
- Last refreshed: 30 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02727296.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing