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NCT06367205
Norepinephrine Infusion Combined With Goal-directed Fluid Therapy in Patients Undergoing Kidney Transplantations
NA trial testing Goal-Directed Fluid Therapy (GDFT) in Delayed Graft Function in 380 participants. Currently enrolling.
30 April 2026
Quick facts
| Lead sponsor | RenJi Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 380 |
| Start date | 1 March 2024 |
| Primary completion | 30 April 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 3 locations across China |
Drugs / interventions tested
- Goal-Directed Fluid Therapy (GDFT) — full drug profile →
- Regular Fluid Therapy — full drug profile →
Conditions studied
- Delayed Graft Function — all drugs for Delayed Graft Function →
- End Stage Renal Disease — all drugs for End Stage Renal Disease →
- Kidney Transplantation — all drugs for Kidney Transplantation →
Sponsor
RenJi Hospital
Who can join
18 and older, any sex, with Delayed Graft Function or End Stage Renal Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Delayed graft function (DGF), delineated by the necessity for dialytic intervention within the initial week post-transplantation, afflicts approximately 20%-50% of recipients. The primary objective of this study is to investigate the potential efficacy of norepinephrine infusion in conjunction with goal-directed fluid therapy (GDFT) in mitigating the occurrence of DGF among individuals undergoing kidney transplantations. The findings of this investigation have the potential to advance the field of perioperative care in kidney transplantations by providing insights into optimized management strategies.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06367205
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Goal-Directed Fluid Therapy (GDFT)
Trials testing the same drug.
- NCT07303855 — Effectiveness of Goal-Directed Fluid Therapy Guided by Cardiac Index Versus Central Venous Pressure in Major Abdominal S · NA · recruiting
- NCT07050979 — Goal-Directed Fluid Therapy for Thoracoscopic Lobectomy · NA · completed
Other recruiting trials for Delayed Graft Function
Currently open trials in the same condition.
- NCT07275632 — The Effects of Vonoprazan Fumarate on DGF Incidence in DD Kidney Transplant Recipients · Phase 1, PHASE2 · recruiting
- NCT06830798 — Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab Admin · Phase 3 · recruiting
- NCT05907096 — ARGX-117 in Deceased Donor Kidney Transplant Recipients at Risk for Delayed Graft Function · Phase 2 · active not recruiting
- NCT05430620 — Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys · Phase 3 · recruiting
- NCT04005469 — Safety and Efficacy of Treprostinil (Remodulin®) In Reducing Ischemia-Reperfusion Injury During Kidney Transplantation · Phase 1, PHASE2 · recruiting
Other RenJi Hospital trials
Trials by the same sponsor.
- NCT07584733 — Biomarker-Enriched Kidney-Preserving Strategy With Disitamab Vedotin Plus Tislelizumab in HER2-Positive High-Risk Upper · Phase 2 · not yet recruiting
- NCT07537725 — EEG-TMS for Postoperative Delirium After Cardiac Surgery · NA · not yet recruiting
- NCT07527936 — A Study of BEN301 Injection in theTreatment of Autoimmune Diseases · EARLY_PHASE1 · not yet recruiting
- NCT07343076 — Efficacy of Immediate Versus Staged Complete Revascularization in Patients With NSTE-ACS and Multivessel Disease (FUTURE · NA · not yet recruiting
- NCT07449793 — Biochemical Response and Clinical Outcomes in Patients With PBC · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06367205 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by RenJi Hospital
- Last refreshed: 16 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06367205.
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