NCT02452450 is a Phase 1 clinical trial of Ibuprofen Acid in Healthy Volunteer Study, sponsored by Reckitt Benckiser Healthcare (UK) Limited.

Who is sponsoring NCT02452450?

NCT02452450 is sponsored by Reckitt Benckiser Healthcare (UK) Limited.

What drugs are being tested in NCT02452450?

Interventions in NCT02452450: Ibuprofen Acid, Ibuprofen Lysine, Ibuprofen Sodium, Ibuprofen Liquid Capsules, Paracetamol.

What condition does NCT02452450 study?

NCT02452450 studies Healthy Volunteer Study.

Is NCT02452450 still recruiting?

NCT02452450 is currently completed. Last updated 22 May 2015.

Last reviewed 2015-05-22 · How we verify

NCT02452450

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ibuprofen and Paracetamol Pharmacokinetic Study

Completed Phase 1 Last updated 22 May 2015

What this trial tests

Phase 1 trial testing Ibuprofen Acid in Healthy Volunteer Study in 43 participants. Completed in 1 October 2014.

Timeline

1 January 2014

Primary endpoint
1 October 2014

1 October 2014

Quick facts

Lead sponsor	Reckitt Benckiser Healthcare (UK) Limited
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	43
Start date	1 January 2014
Primary completion	1 October 2014
Estimated completion	1 October 2014

Drugs / interventions tested

Ibuprofen Acid — full drug profile →
Ibuprofen Lysine — full drug profile →
Ibuprofen Sodium — full drug profile →
Ibuprofen Liquid Capsules — full drug profile →
Paracetamol (Paracetamol) — full drug profile →

Conditions studied

Healthy Volunteer Study — all drugs for Healthy Volunteer Study →

Sponsor

Reckitt Benckiser Healthcare (UK) Limited — full company profile →

Who can join

Adults 18 to 50, any sex, with Healthy Volunteer Study. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Time to the maximum concentration (Cmax) of the reference Ibuprofen
Time frame: 0-4hr
Time to the first extrapolated non-zero concentration (Tlag)
Time frame: 0-4hr
Time to the maximum concentration (Tmax)
Time frame: 0-4hr

Sponsor's own description

The purpose of this study was to determine rates of absorption of Ibuprofen and Paracetamol formulations.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Predicting rapid analgesic onset of ibuprofen salts compared with ibuprofen acid: Tlag, Tlow, Tmed, and a novel parameter, TCmaxRef.
Miles L, Hall J, Jenner B, Addis R, et al · · 2018 · cited 3× · PMID 29667449 · DOI 10.1080/03007995.2018.1466697

Verify or expand the search:

Other recruiting trials for Healthy Volunteer Study

Currently open trials in the same condition.

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Other Reckitt Benckiser Healthcare (UK) Limited trials

Trials by the same sponsor.

NCT06777797 — Prospective, Verification Study to Assess Condom Fit Across Polyurethane (PU) and Natural Rubber Latex (NRL) Condoms · NA · completed
NCT06557499 — A 3-way Crossover Clinical Investigation to Assess the Performance of Two Different Sized Polyurethane Condoms Versus a · NA · recruiting
NCT05840172 — A Clinical Investigation to Assess the Effectiveness of Benzocaine in NRL Condoms in Healthy Adult Men Who Feel They Eja · NA · completed
NCT05644444 — Effectiveness and Safety of a Water-based and a Silicone-based Personal Lubricants With Sensory Action · NA · completed
NCT05689814 — Retention, Stability and Performance Assessment of Denture Fixatives Versus no Fixative Control · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02452450 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Reckitt Benckiser Healthcare (UK) Limited
Last refreshed: 22 May 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02452450.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing