Tubulin — Drug Target

All drugs that target Tubulin — marketed and clinical-stage. Includes 5 drug classes acting on this target.

Drug classes

Microtubule inhibitor · Antimitotic agent · Vascular disrupting agent · Vinca alkaloid · Vinca alkaloid and microtubule inhibitor

Phase 3 pipeline (6)

• SHR-1316、Chemotherapeutic · Jiangsu HengRui Medicine Co., Ltd. · Microtubule inhibitor · Oncology
  SHR-1316 is a chemotherapeutic agent that inhibits tubulin polymerization to disrupt microtubule dynamics and induce cancer cell death.
• Podofilox Gel 0.5% · Dermax SA · Antimitotic agent · Oncology
  Podofilox is a plant-derived antimitotic agent that inhibits cell division.
• Ombrabulin (AVE8062) · Sanofi · Vascular disrupting agent · Oncology
  Ombrabulin is a vascular disrupting agent that binds to tubulin and disrupts microtubule dynamics, causing selective destruction of tumor vasculature and tumor cell death.
• Conventional Vincristine · Universität des Saarlandes · Vinca alkaloid · Oncology
  Vincristine is a vinca alkaloid that binds to tubulin and disrupts microtubule formation, causing cell cycle arrest in metaphase and triggering apoptosis in cancer cells.
• Condylox Topical Gel 0.5% · Dermax SA · Antimitotic agent · Dermatology
  Podophyllotoxin arrests cell division by disrupting microtubule formation, causing necrosis of genital wart tissue.
• treatment Vincristin · Assistance Publique Hopitaux De Marseille · Vinca alkaloid · Oncology
  Vincristine is a vinca alkaloid that binds to tubulin and disrupts microtubule formation, causing cell cycle arrest in metaphase and triggering apoptosis in cancer cells.

Phase 2 pipeline (1)

• Doxil and Vinorelbine · Hematology Oncology Consultants · Vinca alkaloid and microtubule inhibitor · Oncology
  Docetaxel, a microtubule inhibitor, binds to tubulin and prevents microtubule assembly, thereby inhibiting cell division.