What are Vinca alkaloid drugs?

Vinca alkaloid drugs are pharmacologic agents that share a common mechanism (typically targeting β-tubulin). 4 are currently marketed, with 2 more in clinical development.

What are the marketed Vinca alkaloid drugs?

Marketed Vinca alkaloid drugs include VLI, Oncovin, Oncovin, Navelbine.

Vinca alkaloid

4 marketed 2 in Phase 3

This page covers all Vinca alkaloid drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting β-tubulin, Canalicular multispecific organic anion transporter 1, Substance-K receptor.

Targets

β-tubulin · Canalicular multispecific organic anion transporter 1 · Substance-K receptor · Tubulin

Marketed (4)

VLI · Spectrum Pharmaceuticals, Inc · Oncology
VLI is a vinca alkaloid that inhibits microtubule assembly by binding to tubulin, disrupting cell division and causing cell death in rapidly dividing cancer cells.
Oncovin · Pfizer Inc. · Oncology
Oncovin · Pfizer Inc. · Oncology
Navelbine · Pierre Fabre · Oncology
Navelbine works by binding to the Substance-K receptor, disrupting microtubule formation and inhibiting cell division.

Phase 3 pipeline (2)

Conventional Vincristine · Universität des Saarlandes · Oncology
Vincristine is a vinca alkaloid that binds to tubulin and disrupts microtubule formation, causing cell cycle arrest in metaphase and triggering apoptosis in cancer cells.
treatment Vincristin · Assistance Publique Hopitaux De Marseille · Oncology
Vincristine is a vinca alkaloid that binds to tubulin and disrupts microtubule formation, causing cell cycle arrest in metaphase and triggering apoptosis in cancer cells.