Microtubules — Drug Target

All drugs that target Microtubules — marketed and clinical-stage. Includes 6 drug classes acting on this target.

Drug classes

Taxane · Vinca alkaloid and platinum-based chemotherapy · Corticosteroid + Vinca alkaloid · Microtubule inhibitor · Taxane-based chemotherapy · Taxane chemotherapy

Phase 3 pipeline (20)

• concurrent chemotherapy with docetaxel · Air Force Military Medical University, China · Taxane · Oncology
  Docetaxel works by inhibiting microtubule dynamics, thereby inducing apoptosis in cancer cells.
• placebo plus paclitaxel · Biotech Pharmaceutical Co., Ltd. · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from growing and spreading.
• Vincristine, Carboplatin · St. Jude Children's Research Hospital · Vinca alkaloid and platinum-based chemotherapy · Oncology
  Vincristine is a vinca alkaloid that inhibits microtubule formation in the mitotic spindle, resulting in cell cycle arrest at the metaphase.
• Placebo + Paclitaxel · Chengdu Kanghong Biotech Co., Ltd. · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from growing and dividing.
• Taxotere , Epirubicin · National Taiwan University Hospital · Taxane · Oncology
  Taxotere works by inhibiting microtubule formation in the mitotic spindle, resulting in cell cycle arrest at the G2/M phase, and ultimately inducing apoptosis in cancer cells.
• larotaxel (XRP9881) · Sanofi · Taxane · Oncology
  Larotaxel is a taxane dimer that inhibits microtubule dynamics, thereby inducing apoptosis in cancer cells.
• Paclitaxel only · Tata Memorial Hospital · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying.
• Paclitaxel Lipid Suspension · Jina Pharmaceuticals Inc. · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying.
• paclitaxel combined with platinum · Fourth Affiliated Hospital of Guangxi Medical University · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying.
• Prednisone+vincristine · Shanghai Children's Medical Center · Corticosteroid + Vinca alkaloid · Oncology
  Prednisone is a corticosteroid that suppresses the immune system and reduces inflammation, while vincristine is a vinca alkaloid that interferes with microtubule formation in the mitotic spindle, thereby inhibiting cell division.
• Paclitaxel, Docetaxel, Irinotecan · Shanghai Hengrui Pharmaceutical Co., Ltd. · Microtubule inhibitor · Oncology
  Paclitaxel, Docetaxel, and Irinotecan are microtubule inhibitors that work by stabilizing microtubules, thereby inhibiting cell division.
• Paclitaxel dosing according to SmPC · Central European Society for Anticancer Drug Research · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying.
• chemoradiotherapy Paclitaxel · Shandong Cancer Hospital and Institute · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from growing and dividing.
• Paclitaxel based chemotherapy · Cancer Institute and Hospital, Chinese Academy of Medical Sciences · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying and spreading.
• taxane-based chemotherapy · Jenny C. Chang, MD · Taxane-based chemotherapy · Oncology
  Taxanes work by inhibiting microtubule dynamics, thereby preventing cell division and inducing apoptosis in rapidly dividing cancer cells.
• Taxotere (docetaxel) · Seagen Inc. · Taxane · Oncology
  Taxotere (docetaxel) works by inhibiting cell division, ultimately leading to cell death in rapidly dividing cancer cells.
• XRP6976 (Docetaxel/Taxotere) · Sanofi · Taxane · Oncology
  XRP6976 (Docetaxel/Taxotere) works by inhibiting microtubule dynamics, thereby inducing cell cycle arrest and apoptosis in cancer cells.
• local intracoronary dosis of Paclitaxel · University Hospital Tuebingen · Taxane · Oncology
  Paclitaxel works by inhibiting cell division, thereby preventing cancer cells from multiplying.
• Paclical® · Oasmia Pharmaceutical AB · Taxane · Oncology
  Paclical is a formulation of paclitaxel, a microtubule inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells.
• SID530, Taxotere · SK Chemicals Co., Ltd. · Taxane · Oncology
  Taxotere works by inhibiting microtubule formation in the mitotic spindle, resulting in cell cycle arrest at the G2/M phase and apoptosis.

Phase 2 pipeline (5)

• ARD6562, Docetaxel · Sanofi · Taxane · Oncology
  ARD6562, Docetaxel, is a microtubule inhibitor that disrupts cell division.
• Docetaxel only · Samsung Medical Center · Taxane · Oncology
  Docetaxel is a microtubule inhibitor that binds to tubulin and prevents microtubule assembly.
• Docetaxel Polymeric Micelles for Injection · Jiangsu Simcere Pharmaceutical Co., Ltd. · Taxane · Oncology
  Docetaxel inhibits microtubule dynamics by stabilizing microtubules and preventing their depolymerization.
• Albumin-bound Paclitaxone · RemeGen Co., Ltd. · Taxane · Oncology
  Albumin binding enhances the solubility of paclitaxel, allowing for higher doses to be administered.
• Docetaxel-PM · Sung Yong Oh · Taxane chemotherapy · Oncology
  Docetaxel-PM is a taxane chemotherapy medication that works by inhibiting microtubule dynamics, thereby inducing apoptosis in cancer cells.

Phase 1 pipeline (2)

• ABT-348 and docetaxel · AbbVie (prior sponsor, Abbott) · Taxane · Oncology
  Docetaxel is a microtubule inhibitor that works by stabilizing microtubules and preventing cell division.
• AK112, nab-paclitaxel, gemcitabine · Akeso · Taxane · Oncology
  Inhibits microtubule dynamics by binding to tubulin, thereby inhibiting cell division