Estrogen receptor — Drug Target

All drugs that target Estrogen receptor — marketed and clinical-stage. Includes 26 drug classes acting on this target.

Drug classes

Estrogen [EPC] · Radioactive Diagnostic Agent [EPC] · Estrogen · estrone · dienestrol · estrogen receptor degrader · cyclofenil · lasofoxifene · hexestrol · stanozolol · Estrogen Receptor Antagonist [EPC] · estrogen receptor antagonist and degrader

Marketed (19)

• Premarin · Pfizer · Estrogen [EPC] · Metabolic
• Cerianna · GE HealthCare · Radioactive Diagnostic Agent [EPC] · Other
  Cerianna works by binding to estrogen receptors in the body, allowing for imaging of these receptors through positron emission tomography.
• Estradurin · Estrogen · Bone
• Delestrogen · Ph Health · Estrogen · Oncology
  Delestrogen works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen.
• Estron · Watson Labs · estrone · Dermatology
• Synestrol · Johnson & Johnson · dienestrol · Other
• Ortho-Novum 10/11-21 · Merck & Co. · Estrogen · Bone
• Fulvestrant Injectable Product · Pfizer · estrogen receptor degrader · Oncology
• Fertodur · cyclofenil · Other
• Fablyn · Dr. Friedrich Eberth Arzneimittel GmbH · lasofoxifene · Bone
• Hexoestrol · hexestrol · Other
• Norinyl 1+50 28-Day · Estrogen · Nephrology
• Estrace · Pfizer · Estrogen · Oncology
  Estrace works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen.
• Nextstellis · Mayne Pharma · Estrogen · Other
  Nextstellis works by binding to estrogen receptors in the body, mimicking the effects of natural estrogen.
• Menest · Pfizer Inc. · Estrogen · Oncology
  Esterified estrogens, sold under the brand names Estratab and Menest, are used for hormone therapy and cancer treatment.
• Winstrol · stanozolol · Neuroscience
• Orserdu · Stemline Therap · Estrogen Receptor Antagonist [EPC] · Oncology
  Orserdu works by blocking the estrogen receptor, a protein that helps cancer cells grow.
• Palazestrant · Pfizer Inc. · estrogen receptor antagonist and degrader · Oncology
• Phosphestrol · Bayer · fosfestrol · Other

Phase 3 pipeline (15)

• Tamoxifen Citrate Tablets · Shandong Suncadia Medicine Co., Ltd. · Selective estrogen receptor modulator (SERM) · Oncology
  Tamoxifen Citrate Tablets work by competitively inhibiting estrogen receptors on tumor cells.
• XZP-3287+Fulvestrant · Xuanzhu Biopharmaceutical Co., Ltd. · SERD · Oncology
  XZP-3287+Fulvestrant is a combination of XZP-3287 and Fulvestrant, which works by inhibiting the estrogen receptor.
• Standard-of-care endocrine treatment · West German Study Group · Selective estrogen receptor degrader · Oncology
  Blocks estrogen receptors to prevent cancer cell growth.
• Tamoxifen + Aminoglutethimide · Austrian Breast & Colorectal Cancer Study Group · SERM and CYP11A1 inhibitor · Oncology
  Tamoxifen acts as a selective estrogen receptor modulator (SERM) to inhibit estrogen's action in breast tissue, while aminoglutethimide inhibits the enzyme CYP11A1, which is involved in the synthesis of steroids, including estrogen.
• Use of topical estradiol · Women and Infants Hospital of Rhode Island · estrogen agonist · Women's Health
  Topical estradiol acts as an estrogen receptor agonist, exerting its effects locally at the site of application.
• DR-103 · Teva Women's Health · Selective estrogen receptor modulator · Women's Health
  DR-103 is a medication used to treat a specific condition by targeting a particular biological pathway.
• di indolylmethane (DIM) · New York Presbyterian Hospital · Indole · Oncology
  DIM is a natural compound that acts as an estrogen receptor antagonist and a weak estrogen receptor agonist.
• Duration of Treatment: 6 weeks · Organon and Co · Selective estrogen receptor modulator · Gynecology
  This drug works by inhibiting the activity of a specific enzyme.
• Vaginal Estrogen - Twice Weekly · Queen's University · estrogen · Women's Health
  Estrogen replacement therapy to alleviate menopausal symptoms.
• Physician's Choice of Endocrine Therapy · Hoffmann-La Roche · Selective estrogen receptor degrader (SERD) · Oncology
  Physician's Choice of Endocrine Therapy is a treatment that targets hormone receptors to prevent or slow the growth of cancer cells.
• Tamoxifen (Nolvadex) · AstraZeneca · Selective estrogen receptor modulator (SERM) · Oncology
  Tamoxifen acts as a selective estrogen receptor modulator (SERM) to inhibit estrogen's action on breast cancer cells.
• Duration of Treatment: 3 months · Organon and Co · Selective estrogen receptor modulator · Gynecology
  This drug works by inhibiting the activity of a specific enzyme.
• [18F]fluoroestradiol (FES) · Asan Medical Center · Oncology
  FES is a radiolabeled estrogen receptor ligand used for imaging estrogen receptor-positive tumors.
• estradiol (Zesteem) · Renovo · estrogen receptor agonist · Women's Health
  Estradiol acts as an estrogen receptor agonist, mimicking the effects of the naturally occurring hormone estrogen in the body.
• faslodex dummy · AstraZeneca · Selective estrogen receptor degrader (SERD) · Oncology
  Faslodex is a selective estrogen receptor degrader (SERD) that blocks estrogen receptors in breast cancer cells.

Phase 2 pipeline (4)

• Estradiol Transdermal Product · Eastern Virginia Medical School · Estrogen agonist · Oncology
  Estrogen receptor agonist
• INEGY · Organon and Co · Selective estrogen receptor modulator · Women's Health
  Selective estrogen receptor modulator
• Graceptor® · Astellas Pharma Inc · Selective estrogen receptor modulator · Oncology
  Selective estrogen receptor modulator
• Motazomin · molsidomine · Cardiovascular
  Molsidomine works by releasing nitric oxide, which relaxes blood vessels and improves blood flow to the heart.