What development phase is Norinyl 1+50 28-Day in?

Norinyl 1+50 28-Day is FDA-approved (marketed).

What is the generic name of Norinyl 1+50 28-Day?

MESTRANOL is the generic (nonproprietary) name of Norinyl 1+50 28-Day.

Last reviewed 2026-04-20 · How we verify

Norinyl 1+50 28-Day (MESTRANOL)

FDA-approved approved Small molecule Quality 40/100

Norinyl 1+50 28-Day (MESTRANOL) is a small molecule estrogen medication originally developed by G.D. Searle & Company. It is currently owned by Pfizer and targets the estrogen receptor. Approved by the FDA in 1961, it is indicated for contraception, endometriosis, female hypogonadism syndrome, and menorrhagia. Norinyl 1+50 28-Day is off-patent, allowing for generic manufacturing. Key safety considerations include potential risks of blood clots, stroke, and liver disease.

At a glance

Generic name	MESTRANOL
Drug class	Estrogen
Target	Estrogen receptor
Modality	Small molecule
Therapeutic area	Nephrology
Phase	FDA-approved
First approval	1961

Approved indications

Contraception
Endometriosis
Female hypogonadism syndrome
Menorrhagia

Common side effects

No common side effects on file.

Drug interactions

atazanavir
darunavir
fosamprenavir
modafinil
nafcillin
nelfinavir
nevirapine
oxcarbazepine
phenobarbital
phenytoin
primidone
rifabutin

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions