{"id":"mestranol","rwe":[{"pmid":"41131613","year":"2025","title":"Muscle quality decline and fat infiltration in non-elderly OSA patients: associations with metabolic abnormalities.","finding":"","journal":"Journal of translational medicine","studyType":"Clinical Study"},{"pmid":"40957191","year":"2025","title":"Metabolite profiling in human and mouse liver microsomes of the aminosteroid RM-581, a new orally active anticancer agent.","finding":"","journal":"Bioorganic chemistry","studyType":"Clinical Study"},{"pmid":"40886205","year":"2025","title":"Impacts of rural and urban sources on a tropical semiarid region (Acaraú River, Ceará, Brazil): sedimentary sterols and endocrine-disrupting compounds as anthropogenic molecular markers.","finding":"","journal":"Environmental geochemistry and health","studyType":"Clinical Study"},{"pmid":"40664780","year":"2025","title":"Exploring the mechanism of metabolic cell death-related genes AKR1C2 and MAP1LC3A as biomarkers in Parkinson's 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Phenobarbital","source":"DrugCentral","drugSlug":"phenobarbital"},{"url":"/drug/phenytoin","drug":"phenytoin","action":"Monitor closely","effect":"May interact with Phenytoin","source":"DrugCentral","drugSlug":"phenytoin"},{"url":"/drug/primidone","drug":"primidone","action":"Monitor closely","effect":"May interact with Primidone","source":"DrugCentral","drugSlug":"primidone"},{"url":"/drug/rifabutin","drug":"rifabutin","action":"Avoid combination","effect":"May interact with Rifabutin","source":"DrugCentral","drugSlug":"rifabutin"},{"url":"/drug/rifampicin","drug":"rifampicin","action":"Avoid combination","effect":"May interact with Rifampin","source":"DrugCentral","drugSlug":"rifampicin"},{"url":"/drug/rifapentine","drug":"rifapentine","action":"Avoid combination","effect":"May interact with Rifapentine","source":"DrugCentral","drugSlug":"rifapentine"},{"url":"/drug/ritonavir","drug":"ritonavir","action":"Avoid combination","effect":"May interact with Ritonavir","source":"DrugCentral","drugSlug":"ritonavir"},{"url":"/drug/rufinamide","drug":"rufinamide","action":"Avoid combination","effect":"May interact with Rufinamide","source":"DrugCentral","drugSlug":"rufinamide"},{"url":"/drug/saquinavir","drug":"saquinavir","action":"Monitor closely","effect":"May interact with Saquinavir","source":"DrugCentral","drugSlug":"saquinavir"},{"url":"/drug/secobarbital","drug":"secobarbital","action":"Monitor closely","effect":"May interact with Secobarbital","source":"DrugCentral","drugSlug":"secobarbital"},{"url":"/drug/tipranavir","drug":"tipranavir","action":"Monitor closely","effect":"May interact with Tipranavir","source":"DrugCentral","drugSlug":"tipranavir"},{"url":"/drug/topiramate","drug":"topiramate","action":"Monitor closely","effect":"May interact with Topiramate","source":"DrugCentral","drugSlug":"topiramate"}],"contraindications":["Angina pectoris","Benign mammary dysplasia","Body fluid retention","Carcinoma of female breast","Cardiovascular event risk","Cerebrovascular accident","Cholestasis of pregnancy","Deep venous thrombosis","Depressive disorder","Diabetes mellitus","Disease of liver","Disorder of coronary artery","Disorder of gallbladder","Endometrial carcinoma","Estrogen receptor positive tumor","Heart valve disorder","Hypercholesterolemia","Hyperglycemia","Hyperlipidemia","Hypertensive disorder","Hypertensive urgency","Hypertriglyceridemia","Intermenstrual bleeding - irregular","Liver function tests abnormal","Major Surgery with Prolonged Post-Operative Immobilization"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=MESTRANOL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:46:33.538085+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada 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Searle & Company. It is currently owned by Pfizer and targets the estrogen receptor. Approved by the FDA in 1961, it is indicated for contraception, endometriosis, female hypogonadism syndrome, and menorrhagia. Norinyl 1+50 28-Day is off-patent, allowing for generic manufacturing. 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