Last reviewed · How we verify
Use of topical estradiol
Topical estradiol acts as an estrogen receptor agonist, exerting its effects locally at the site of application.
Topical estradiol acts as an estrogen receptor agonist, exerting its effects locally at the site of application. Used for Treatment of vaginal atrophy in postmenopausal women.
At a glance
| Generic name | Use of topical estradiol |
|---|---|
| Sponsor | Women and Infants Hospital of Rhode Island |
| Drug class | estrogen agonist |
| Target | estrogen receptor |
| Modality | Small molecule |
| Therapeutic area | Women's Health |
| Phase | Phase 3 |
Mechanism of action
Topical estradiol binds to estrogen receptors in the skin, stimulating the growth of new skin cells and improving skin hydration. This can help alleviate symptoms of menopause, such as vaginal dryness and itching.
Approved indications
- Treatment of vaginal atrophy in postmenopausal women
Common side effects
- Vaginal discharge
- Vaginal itching
- Breast tenderness
Key clinical trials
- Er:YAG Laser Combined With Vaginal Estriol for Genitourinary Syndrome of Menopause (NA)
- Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial (PHASE2, PHASE3)
- Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse (PHASE4)
- Human Cerebral Blood Flow Regulation (EARLY_PHASE1)
- Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy (PHASE3)
- Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial (PHASE4)
- Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism (NA)
- Evaluation of Fractional CO2 Laser Treatment Efficacy and Comparison to Vaginal Estrogen Therapy in Postmenopausal Women With Vulvovaginal Atrophy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Use of topical estradiol CI brief — competitive landscape report
- Use of topical estradiol updates RSS · CI watch RSS
- Women and Infants Hospital of Rhode Island portfolio CI