Who are Use of topical estradiol's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Orserdu, Nextstellis, Cerianna, Osphena, Duavee, Duavee.

How often does this brief refresh?

Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-17 · How we verify

Use of topical estradiol — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Use of topical estradiol (Use of topical estradiol) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: estrogen agonist. Area: Women's Health.

phase 3 estrogen agonist estrogen receptor Women's Health Small molecule Live · refreshed every 30 min

Target snapshot

Use of topical estradiol (Use of topical estradiol) — Women and Infants Hospital of Rhode Island. Topical estradiol acts as an estrogen receptor agonist, exerting its effects locally at the site of application.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Use of topical estradiol TARGET	Use of topical estradiol	Women and Infants Hospital of Rhode Island	phase 3	estrogen agonist	estrogen receptor
Orserdu	ELACESTRANT	Stemline Therap	marketed	Estrogen Receptor Antagonist [EPC]	Estrogen receptor	2023-01-01
Nextstellis	ESTETROL	Mayne Pharma	marketed	Estrogen	Estrogen receptor	2021-01-01
Cerianna	FLUOROESTRADIOL F-18	GE HealthCare	marketed	Radioactive Diagnostic Agent [EPC]	Estrogen receptor	2020-01-01
Osphena	OSPEMIFENE	Duchesnay	marketed	Estrogen Agonist/Antagonist [EPC]	Estrogen receptor beta	2013-01-01
Duavee	BAZEDOXIFENE	Wyeth Pharms Pfizer	marketed	Estrogen [EPC]	estrogen receptors (ER) α and β	2013-01-01
Duavee	conjugated-estrogens-bazedoxifene	Pfizer	marketed	Estrogen [EPC]	estrogen receptors α and β	2013-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2027-03-10 — Duavee · 7683051 · US

Sponsor landscape (estrogen agonist class)

Women and Infants Hospital of Rhode Island · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Use of topical estradiol — Competitive Intelligence Brief. https://druglandscape.com/ci/use-of-topical-estradiol. Accessed 2026-05-17.

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