DNA topoisomerase 2-alpha — Drug Target

All drugs that target DNA topoisomerase 2-alpha — marketed and clinical-stage. Includes 5 drug classes acting on this target.

Drug classes

Topoisomerase Inhibitor [EPC] · Anthracycline Topoisomerase Inhibitor · Cytoprotective Agent · carubicin · asulacrine

Marketed (3)

• Vepesid · Bristol-Myers Squibb K.K. · Topoisomerase Inhibitor [EPC] · Oncology
• Idamycin Pfs · Anthracycline Topoisomerase Inhibitor · Oncology
  Idarubicin works by binding to DNA topoisomerase 2-alpha, preventing the enzyme from unwinding DNA and leading to cell death.
• Zinecard · Pfizer · Cytoprotective Agent · Oncology
  Zinecard works by binding to metal ions and preventing them from causing damage to DNA during anthracycline treatment.

Phase 2 pipeline (1)

• Carminomicin I · carubicin · Other
  CARUBICIN works by binding to DNA topoisomerase 2-alpha, preventing the enzyme from unwinding DNA and leading to cell death.