Cytoprotective agent

This page covers all Cytoprotective agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Aspartyl/asparaginyl beta-hydroxylase, DNA topoisomerase 2-alpha.

Targets

Aspartyl/asparaginyl beta-hydroxylase · DNA topoisomerase 2-alpha

Marketed (3)

• amifostine trihydrate · City of Hope Medical Center · Oncology
  Amifostine is a prodrug that is converted to an active free thiol compound, which acts as a cytoprotective and radioprotective agent by scavenging free radicals and reducing DNA damage.
• Blenoxane · Bristol-Myers Squibb · Oncology
  Bleomycin works by binding to DNA and causing strand breaks, which ultimately leads to cell death.
• Zinecard · Pfizer · Oncology
  Zinecard works by binding to metal ions and preventing them from causing damage to DNA during anthracycline treatment.