Anthracycline Topoisomerase Inhibitor

This page covers all Anthracycline Topoisomerase Inhibitor drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting DNA, topoisomerase II, Histone deacetylase 6, DNA, Topoisomerase II.

Targets

DNA, topoisomerase II · Histone deacetylase 6 · DNA, Topoisomerase II · DNA topoisomerase 2-alpha · Aurora kinase A · Tyrosine-protein kinase Fyn · DNA topoisomerase II, nucleotide bases

Marketed (8)

• Idamycin Pfs · Oncology
  Idarubicin hydrochloride exerts its effects by forming DNA complexes, inhibiting nucleic acid synthesis, blocking topoisomerase II, and generating DNA-damaging free radicals.
• Daunorubicin Hydrochloride · Meiji Seika Pharma Co., Ltd · Oncology
• Idamycin Pfs · Pfizer Inc.
  Idarubicin forms DNA complexes, inhibits nucleic acid synthesis and topoisomerase II, produces DNA-damaging free radicals.
• Idamycin Pfs · Oncology
  Idarubicin works by binding to DNA topoisomerase 2-alpha, preventing the enzyme from unwinding DNA and leading to cell death.
• Doxorubicin Hydrochloride · Pfizer · Oncology
  Doxorubicin works by intercalating DNA strands and inhibiting topoisomerase II, an enzyme essential for DNA replication and cell division.
• Idamycin Pfs · Pfizer Inc. · Oncology
  Idarubicin forms DNA complexes, inhibits nucleic acid synthesis and topoisomerase II, produces DNA-damaging free radicals.
• Ellence · Pfizer · Oncology
  Ellence works by intercalating DNA and inhibiting topoisomerase II, disrupting cancer cell growth.
• Doxorubicin Hydrochloride · Pfizer Inc. · Oncology
  Doxorubicin intercalates nucleotide bases and interacts with topoisomerase II to form DNA-cleavable complexes, inhibiting DNA/RNA replication.