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Idamycin Pfs (Idarubicin Hydrochloride)

Pfizer Inc. · FDA-approved approved Small molecule Quality 61/100

Idarubicin forms DNA complexes, inhibits nucleic acid synthesis and topoisomerase II, produces DNA-damaging free radicals.

Idarubicin is an anthracycline topoisomerase inhibitor indicated for adult acute myeloid leukemia as part of combination chemotherapy. The drug demonstrates potent cytotoxic activity through DNA binding, topoisomerase II inhibition, and free radical generation. Idarubicin undergoes extensive metabolism to the active metabolite idarubicinol with sustained plasma levels exceeding 8 days. No contraindications are listed, though effects of renal or hepatic impairment on pharmacokinetics remain unknown.

At a glance

Generic nameIdarubicin Hydrochloride
SponsorPfizer Inc.
Drug classAnthracycline topoisomerase inhibitor
TargetDNA, Topoisomerase II
ModalitySmall molecule
Therapeutic areaOncology
PhaseFDA-approved
First approval1990

Mechanism of action

Idarubicin hydrochloride exhibits antimitotic and cytotoxic activity through multiple mechanisms of action. The drug forms complexes with DNA and inhibits nucleic acid synthesis, preventing cell replication. Additionally, idarubicin inhibits topoisomerase II activity and produces DNA-damaging free radicals, leading to cell death through multiple pathways.

Approved indications

Common side effects

Primary sources

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SourceUsed for
FDA labelMechanism, indications, dosing, boxed warnings, drug interactions

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