5-HT3 receptor — Drug Target

All drugs that target 5-HT3 receptor — marketed and clinical-stage. Includes 3 drug classes acting on this target.

Drug classes

5-HT3 receptor antagonist · Serotonin 5-HT3 receptor antagonist · serotonin receptor antagonist

Marketed (12)

• Zofran inj.+Zofran tab. · LG Life Sciences · 5-HT3 receptor antagonist · Oncology, Gastroenterology, Anesthesia
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• ondansetron (Zofran) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · 5-HT3 receptor antagonist · Gastroenterology / Oncology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• cardiac output changes with "ondansetron" · University Tunis El Manar · 5-HT3 receptor antagonist · Oncology, Gastroenterology, Anesthesia
  Ondansetron is a 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Treatment 2 Ondansetron · Hamad Medical Corporation · 5-HT3 receptor antagonist · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Ondansetron (ODT) · MonoSol Rx · 5-HT3 receptor antagonist · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Ondansetron orodispersible film once · Chongqing University Cancer Hospital · 5-HT3 receptor antagonist · Oncology / Gastroenterology
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Granisetron (Group G) · University of Malaya · 5-HT3 receptor antagonist · Oncology, Gastroenterology
  Granisetron is a selective serotonin 5-HT3 receptor antagonist that blocks nausea and vomiting signals in the chemoreceptor trigger zone and gastrointestinal tract.
• Ondansetron Intraperitoneal Lavage · Instituto Mexicano del Seguro Social · 5-HT3 receptor antagonist · Gastroenterology / Oncology
  Ondansetron blocks serotonin 5-HT3 receptors in the peritoneal cavity to prevent nausea and vomiting during intraperitoneal lavage procedures.
• Sancuso patch · LG Life Sciences · 5-HT3 receptor antagonist · Oncology
  Sancuso is a granisetron transdermal patch that blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Kytril inj.+Kytril tab. · LG Life Sciences · 5-HT3 receptor antagonist · Oncology, Anesthesia
  Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Palonosetron only · NYU Langone Health · 5-HT3 receptor antagonist · Oncology / Supportive Care
  Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Palonosetron (Group P) · University of Malaya · 5-HT3 receptor antagonist · Oncology, Gastroenterology
  Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.

Phase 3 pipeline (12)

• Experimental drug: Ondansetron · CCTU · 5-HT3 receptor antagonist · Oncology, Gastroenterology, Anesthesia
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Oral palonosetron · Helsinn Healthcare SA · 5-HT3 receptor antagonist · Oncology
  Palonosetron works by blocking serotonin 5-HT3 receptors in the body, which helps to prevent nausea and vomiting.
• Granisetron Injection · Eye & ENT Hospital of Fudan University · 5-HT3 receptor antagonist · Oncology
  Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• I.V. palonosetron · Helsinn Healthcare SA · 5-HT3 receptor antagonist · Oncology
  Palonosetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• IV ondansetron hydrochloride · GlaxoSmithKline · 5-HT3 receptor antagonist · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Placebo to Ondansetron · Helsinn Healthcare SA · 5-HT3 receptor antagonist · Oncology, Gastroenterology, Anesthesia
  Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Ondansetron oral tablets · GlaxoSmithKline · Serotonin 5-HT3 receptor antagonist · Oncology
  Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.
• Placebo to Palonosetron · Helsinn Healthcare SA · 5-HT3 receptor antagonist · Oncology
  Palonosetron works by blocking serotonin 5-HT3 receptors in the body, which helps to prevent nausea and vomiting caused by chemotherapy.
• Ondansetron Oral Soluble Pellicles · The First Affiliated Hospital of Xinxiang Medical College · Serotonin 5-HT3 receptor antagonist · Oncology
  Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.
• Comparator: ondansetron IV · Merck Sharp & Dohme LLC · 5-HT3 receptor antagonist · Supportive Care / Antiemetic
  Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Standard: Ondansetron · CCTU · Serotonin 5-HT3 receptor antagonist · Oncology
  Ondansetron works by blocking serotonin receptors in the body, which helps to reduce nausea and vomiting.
• Placebo followed by Ondansetron · University of Colorado, Denver · 5-HT3 receptor antagonist · Supportive Care / Antiemetic
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.

Phase 2 pipeline (2)

• GRT6005 · Tris Pharma, Inc. · serotonin receptor antagonist · Gastrointestinal
  GRT6005 is a small molecule drug that targets the serotonin receptor.
• BEKINDA · RedHill Biopharma Limited · Serotonin 5-HT3 receptor antagonist · Gastroenterology
  Bekinda is a delayed-release tablet formulation of ondansetron, a serotonin 5-HT3 receptor antagonist.