5-HT3 receptor antagonist

This page covers all 5-HT3 receptor antagonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting 5-HT3 receptor.

Targets

5-HT3 receptor

Marketed (12)

• cardiac output changes with "ondansetron" · University Tunis El Manar · Oncology, Gastroenterology, Anesthesia
  Ondansetron is a 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Kytril inj.+Kytril tab. · LG Life Sciences · Oncology, Anesthesia
  Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Zofran inj.+Zofran tab. · LG Life Sciences · Oncology, Gastroenterology, Anesthesia
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Ondansetron orodispersible film once · Chongqing University Cancer Hospital · Oncology / Gastroenterology
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Sancuso patch · LG Life Sciences · Oncology
  Sancuso is a granisetron transdermal patch that blocks serotonin 5-HT3 receptors in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Ondansetron Intraperitoneal Lavage · Instituto Mexicano del Seguro Social · Gastroenterology / Oncology
  Ondansetron blocks serotonin 5-HT3 receptors in the peritoneal cavity to prevent nausea and vomiting during intraperitoneal lavage procedures.
• Treatment 2 Ondansetron · Hamad Medical Corporation · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Palonosetron only · NYU Langone Health · Oncology / Supportive Care
  Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Palonosetron (Group P) · University of Malaya · Oncology, Gastroenterology
  Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Ondansetron (ODT) · MonoSol Rx · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Granisetron (Group G) · University of Malaya · Oncology, Gastroenterology
  Granisetron is a selective serotonin 5-HT3 receptor antagonist that blocks nausea and vomiting signals in the chemoreceptor trigger zone and gastrointestinal tract.
• ondansetron (Zofran) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) · Gastroenterology / Oncology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.

Phase 3 pipeline (9)

• Granisetron Injection · Eye & ENT Hospital of Fudan University · Oncology
  Granisetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Oral palonosetron · Helsinn Healthcare SA · Oncology
  Palonosetron works by blocking serotonin 5-HT3 receptors in the body, which helps to prevent nausea and vomiting.
• Placebo to Ondansetron · Helsinn Healthcare SA · Oncology, Gastroenterology, Anesthesia
  Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• IV ondansetron hydrochloride · GlaxoSmithKline · Oncology, Gastroenterology
  Ondansetron blocks serotonin (5-HT3) receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Comparator: ondansetron IV · Merck Sharp & Dohme LLC · Supportive Care / Antiemetic
  Ondansetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• I.V. palonosetron · Helsinn Healthcare SA · Oncology
  Palonosetron is a selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.
• Placebo followed by Ondansetron · University of Colorado, Denver · Supportive Care / Antiemetic
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.
• Placebo to Palonosetron · Helsinn Healthcare SA · Oncology
  Palonosetron works by blocking serotonin 5-HT3 receptors in the body, which helps to prevent nausea and vomiting caused by chemotherapy.
• Experimental drug: Ondansetron · CCTU · Oncology, Gastroenterology, Anesthesia
  Ondansetron blocks serotonin 5-HT3 receptors on chemoreceptor trigger zone and vagal afferent nerves to prevent nausea and vomiting.