Is there a generic for Lyrica?

Yes — 11 approved generic versions of Lyrica (Pregabalin) are tracked in our index. Generic substitution is typically automatic at the pharmacy unless the prescriber writes "dispense as written."

How much cheaper is generic Pregabalin?

Generic small-molecule drugs typically launch at 60-80% discount to the originator. After multiple manufacturers enter the market (12-24 months post-cliff), prices drop further to 85-95% below originator. Your insurance copay may not reflect the full savings — check the cash price too.

Are generics as effective as the brand?

For small-molecule drugs: yes. Generics are required to demonstrate bioequivalence — identical active ingredient, same dose, same route, same indication. Pharmacokinetic equivalence within tight bounds (±20% AUC + Cmax). Most patients can switch without clinical effect.

When did Lyrica go generic?

Generic Pregabalin entered the US market when the originator's exclusivity expired. See the patent timeline below for specific dates.

Last reviewed 2026-06-10 · How we verify

Lyrica generic

Complete generic competition for Lyrica (Pregabalin): 11 approved generics across manufacturers, 0 filed under FDA review. 6 active patents remain. Sourced from FDA Orange Book + USPTO.

11 approved generics 6 active patents

About Lyrica

Lyrica (Pregabalin) — originally marketed by Pfizer Inc.. Class: Anticonvulsant, analgesic.

Approved generic versions (11)

Generic	Manufacturer	Phase
Pregabalin and dexmedetomidine	Wonkwang University Hospital	marketed
Pregabalin and Oxcarbazepine	Ju Seok Ryu	marketed
Pregabalin 300mg	University of Missouri-Columbia	marketed
Pregabalin; Dexamethasone	Glostrup University Hospital, Copenhagen	marketed
Pregabalin 25 MG	Ajou University School of Medicine	marketed
Pregabalin capsule	Guang'anmen Hospital of China Academy of Chinese Medical Sciences	marketed
pregabalin and celecoxib	Pfizer's Upjohn has merged with Mylan to form Viatris Inc.	marketed
pregabalin 450 mg	Viatris Specialty LLC	marketed
Pregabalin-Lyrica	Rush University Medical Center	marketed
Pregabalin 50mg	Hospital for Special Surgery, New York	marketed
pregabalin capsules	AstraZeneca	marketed

Originator patent timeline

Active patents (6)

2027-05-02 — 9144559*PED · Compound · US
2027-05-02 — 10022447*PED · Compound · US
2027-05-02 — 8945620*PED · Compound · US
2026-11-02 — 10022447 · Method of Use · US
2026-11-02 — 8945620 · Formulation · US
2026-11-02 — 9144559 · Formulation · US

Expired patents (0)

No expired patents tracked.

How small-molecule generic approval works

Generic versions of small-molecule drugs are approved by the FDA via the Abbreviated New Drug Application (ANDA) pathway under the Hatch-Waxman Act of 1984. Sponsors must demonstrate bioequivalence (pharmacokinetic equivalence within tight bounds) and identical chemical composition — no clinical trials in patients are required. Approval typically takes 18-24 months.

This is different from biosimilars for biologic drugs, which use the more complex 351(k) BLA pathway and typically achieve smaller (15-35%) discounts vs the originator. Small-molecule generics typically launch at 60-80% discount, dropping to 85-95% within 2 years.

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Lyrica full drug profile
Biosimilar tracker (for biologic drugs)
Patent cliff tracker
Biosimilar vs generic — what's the difference?

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing